CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

Abstract Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians fro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carmen Martin-Ruiz, Jedrzej Hoffmann, Evgeniya Shmeleva, Thomas von Zglinicki, Gavin Richardson, Lilia Draganova, Rachael Redgrave, Joanna Collerton, Helen Arthur, Bernard Keavney, Ioakim Spyridopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/6c6164b48b09434e8151f284b40d511a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c6164b48b09434e8151f284b40d511a
record_format	dspace
spelling	oai:doaj.org-article:6c6164b48b09434e8151f284b40d511a2021-12-02T14:26:47ZCMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians10.1038/s41514-019-0041-y2056-3973https://doaj.org/article/6c6164b48b09434e8151f284b40d511a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41514-019-0041-yhttps://doaj.org/toc/2056-3973Abstract Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the same birth cohort together with NT-proBNP measurements and followed all participants over 7 years. We found that, independent of CMV serostatus, a high number of CD27−CD28+ CD8 EMRA T-lymphocytes (TEMRA) protected from all-cause death after adjusting for known risk factors, such as heart failure, frailty or cancer (Hazard ratio 0.66 for highest vs lowest tertile; confidence interval 0.51–0.86). In addition, CD27−CD28+ CD8 EMRA T-lymphocytes protected from both, non-cardiovascular (hazard ratio 0.59) and cardiovascular death (hazard ratio 0.65). In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show whether targeting immunosenescence will lead to enhanced life- or healthspan.Carmen Martin-RuizJedrzej HoffmannEvgeniya ShmelevaThomas von ZglinickiGavin RichardsonLilia DraganovaRachael RedgraveJoanna CollertonHelen ArthurBernard KeavneyIoakim SpyridopoulosNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Carmen Martin-Ruiz Jedrzej Hoffmann Evgeniya Shmeleva Thomas von Zglinicki Gavin Richardson Lilia Draganova Rachael Redgrave Joanna Collerton Helen Arthur Bernard Keavney Ioakim Spyridopoulos CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
description	Abstract Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the same birth cohort together with NT-proBNP measurements and followed all participants over 7 years. We found that, independent of CMV serostatus, a high number of CD27−CD28+ CD8 EMRA T-lymphocytes (TEMRA) protected from all-cause death after adjusting for known risk factors, such as heart failure, frailty or cancer (Hazard ratio 0.66 for highest vs lowest tertile; confidence interval 0.51–0.86). In addition, CD27−CD28+ CD8 EMRA T-lymphocytes protected from both, non-cardiovascular (hazard ratio 0.59) and cardiovascular death (hazard ratio 0.65). In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show whether targeting immunosenescence will lead to enhanced life- or healthspan.
format	article
author	Carmen Martin-Ruiz Jedrzej Hoffmann Evgeniya Shmeleva Thomas von Zglinicki Gavin Richardson Lilia Draganova Rachael Redgrave Joanna Collerton Helen Arthur Bernard Keavney Ioakim Spyridopoulos
author_facet	Carmen Martin-Ruiz Jedrzej Hoffmann Evgeniya Shmeleva Thomas von Zglinicki Gavin Richardson Lilia Draganova Rachael Redgrave Joanna Collerton Helen Arthur Bernard Keavney Ioakim Spyridopoulos
author_sort	Carmen Martin-Ruiz
title	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
title_short	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
title_full	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
title_fullStr	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
title_full_unstemmed	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
title_sort	cmv-independent increase in cd27−cd28+ cd8+ emra t cells is inversely related to mortality in octogenarians
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c6164b48b09434e8151f284b40d511a
work_keys_str_mv	AT carmenmartinruiz cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT jedrzejhoffmann cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT evgeniyashmeleva cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT thomasvonzglinicki cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT gavinrichardson cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT liliadraganova cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT rachaelredgrave cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT joannacollerton cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT helenarthur cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT bernardkeavney cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians AT ioakimspyridopoulos cmvindependentincreaseincd27cd28cd8emratcellsisinverselyrelatedtomortalityinoctogenarians
_version_	1718391315589234688

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

Ejemplares similares