Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors

Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC...

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Autores principales:	Amanda Rosewell Shaw, Caroline E. Porter, Tiffany Yip, Way-Champ Mah, Mary K. McKenna, Matthew Dysthe, Youngrock Jung, Robin Parihar, Malcolm K. Brenner, Masataka Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6c619b9e136441a696783c518011c56f
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spelling	oai:doaj.org-article:6c619b9e136441a696783c518011c56f2021-12-02T17:05:09ZOncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors10.1038/s42003-021-01914-82399-3642https://doaj.org/article/6c619b9e136441a696783c518011c56f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01914-8https://doaj.org/toc/2399-3642Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC xenografts and humanized mouse models.Amanda Rosewell ShawCaroline E. PorterTiffany YipWay-Champ MahMary K. McKennaMatthew DystheYoungrock JungRobin PariharMalcolm K. BrennerMasataka SuzukiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
description	Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC xenografts and humanized mouse models.
format	article
author	Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki
author_facet	Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki
author_sort	Amanda Rosewell Shaw
title	Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
title_short	Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
title_full	Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
title_fullStr	Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
title_full_unstemmed	Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
title_sort	oncolytic adeno-immunotherapy modulates the immune system enabling car t-cells to cure pancreatic tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c619b9e136441a696783c518011c56f
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Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors

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