Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic insights into the recruitment of Glu-rich motif-conta...

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Autores principales: Amit Meir, David Chetrit, Luying Liu, Craig R. Roy, Gabriel Waksman
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6c642b7b193d45158274212a71865767
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spelling oai:doaj.org-article:6c642b7b193d45158274212a718657672021-12-02T15:34:06ZLegionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system10.1038/s41467-017-02578-x2041-1723https://doaj.org/article/6c642b7b193d45158274212a718657672018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02578-xhttps://doaj.org/toc/2041-1723Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic insights into the recruitment of Glu-rich motif-containing effectors to the T4BSS.Amit MeirDavid ChetritLuying LiuCraig R. RoyGabriel WaksmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amit Meir
David Chetrit
Luying Liu
Craig R. Roy
Gabriel Waksman
Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
description Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic insights into the recruitment of Glu-rich motif-containing effectors to the T4BSS.
format article
author Amit Meir
David Chetrit
Luying Liu
Craig R. Roy
Gabriel Waksman
author_facet Amit Meir
David Chetrit
Luying Liu
Craig R. Roy
Gabriel Waksman
author_sort Amit Meir
title Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
title_short Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
title_full Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
title_fullStr Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
title_full_unstemmed Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
title_sort legionella dotm structure reveals a role in effector recruiting to the type 4b secretion system
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6c642b7b193d45158274212a71865767
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AT luyingliu legionelladotmstructurerevealsaroleineffectorrecruitingtothetype4bsecretionsystem
AT craigrroy legionelladotmstructurerevealsaroleineffectorrecruitingtothetype4bsecretionsystem
AT gabrielwaksman legionelladotmstructurerevealsaroleineffectorrecruitingtothetype4bsecretionsystem
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