Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life

Hydropinotherapy is a salus per aquam (Spa) treatment suitable as a complementary approach to treat several diseases, which strongly affect the quality of life (QoL). Hydropinotherapy with sulphurous mineral water exerts benefits thanks to components, such as hydrogen sulphide, which is considered m...

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Autores principales:	Maria Costantino, Valeria Conti, Graziamaria Corbi, Amelia Filippelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sulphurous mineral water glycaemia oxidative stress ROMs quality of life Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6c64938c69194dd6b8dd6b31989d14b6
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spelling	oai:doaj.org-article:6c64938c69194dd6b8dd6b31989d14b62021-11-25T16:28:16ZHydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life10.3390/antiox101117732076-3921https://doaj.org/article/6c64938c69194dd6b8dd6b31989d14b62021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1773https://doaj.org/toc/2076-3921Hydropinotherapy is a salus per aquam (Spa) treatment suitable as a complementary approach to treat several diseases, which strongly affect the quality of life (QoL). Hydropinotherapy with sulphurous mineral water exerts benefits thanks to components, such as hydrogen sulphide, which is considered mainly responsible for antioxidant and hypoglycaemic effects. Such properties, linked from each other, could favour an improvement in patients’ QoL. However, data on humans are scarce. This study aimed to investigate whether a cycle of sulphurous hydropinotherapy was able to modify plasma levels of glucose and reactive oxygen metabolites (ROMs) and improve QoL in patients suffering from several chronic disorders. A prospective, observational study involved patients with gastrointestinal diseases who received a prescription of a cycle of sulphurous hydropinotherapy (S-HT). Age- and sex-matched control group was enrolled (No S-HT). Glycaemia and plasma concentration of ROMs were measured in all subjects. The impact of spa treatment on the QoL was assessed using the Short Form 36 Health Status Survey questionnaire (SF-36). All parameters were measured at baseline and at the end of a 2-week treatment. Between the groups, no differences were found in glycaemia and ROMs at baseline. In the S-HT group, a reduction in glycaemia and ROMs, both in respect to baseline (<i>p</i> = 0.005 and <i>p</i> = 0.031, respectively) and to control group, as shown by the delta value calculated, as the difference between the values at 2 weeks and baseline (<i>p</i> = 0.0009 and <i>p</i> = 0.0001, respectively). In the S-HT, delta ROMs was the best predictor of delta glycaemia with a direct linear correlation (beta = 0.559, 95% CI 0.471 to 0.647, <i>p</i> < 0.0001). In the S-HT, the SF-36 total score was improved both when compared with baseline (<i>p</i> = 0.002) and with No S-HT (<i>p</i> = 0.001). Sulphurous hydropinotherapy induces a decrease in glycaemia and ROM levels, also ameliorating the patients’ QoL. Therefore, it could be considered a useful complementary therapeutic approach.Maria CostantinoValeria ContiGraziamaria CorbiAmelia FilippelliMDPI AGarticlesulphurous mineral waterglycaemiaoxidative stressROMsquality of lifeTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1773, p 1773 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sulphurous mineral water glycaemia oxidative stress ROMs quality of life Therapeutics. Pharmacology RM1-950
spellingShingle	sulphurous mineral water glycaemia oxidative stress ROMs quality of life Therapeutics. Pharmacology RM1-950 Maria Costantino Valeria Conti Graziamaria Corbi Amelia Filippelli Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
description	Hydropinotherapy is a salus per aquam (Spa) treatment suitable as a complementary approach to treat several diseases, which strongly affect the quality of life (QoL). Hydropinotherapy with sulphurous mineral water exerts benefits thanks to components, such as hydrogen sulphide, which is considered mainly responsible for antioxidant and hypoglycaemic effects. Such properties, linked from each other, could favour an improvement in patients’ QoL. However, data on humans are scarce. This study aimed to investigate whether a cycle of sulphurous hydropinotherapy was able to modify plasma levels of glucose and reactive oxygen metabolites (ROMs) and improve QoL in patients suffering from several chronic disorders. A prospective, observational study involved patients with gastrointestinal diseases who received a prescription of a cycle of sulphurous hydropinotherapy (S-HT). Age- and sex-matched control group was enrolled (No S-HT). Glycaemia and plasma concentration of ROMs were measured in all subjects. The impact of spa treatment on the QoL was assessed using the Short Form 36 Health Status Survey questionnaire (SF-36). All parameters were measured at baseline and at the end of a 2-week treatment. Between the groups, no differences were found in glycaemia and ROMs at baseline. In the S-HT group, a reduction in glycaemia and ROMs, both in respect to baseline (<i>p</i> = 0.005 and <i>p</i> = 0.031, respectively) and to control group, as shown by the delta value calculated, as the difference between the values at 2 weeks and baseline (<i>p</i> = 0.0009 and <i>p</i> = 0.0001, respectively). In the S-HT, delta ROMs was the best predictor of delta glycaemia with a direct linear correlation (beta = 0.559, 95% CI 0.471 to 0.647, <i>p</i> < 0.0001). In the S-HT, the SF-36 total score was improved both when compared with baseline (<i>p</i> = 0.002) and with No S-HT (<i>p</i> = 0.001). Sulphurous hydropinotherapy induces a decrease in glycaemia and ROM levels, also ameliorating the patients’ QoL. Therefore, it could be considered a useful complementary therapeutic approach.
format	article
author	Maria Costantino Valeria Conti Graziamaria Corbi Amelia Filippelli
author_facet	Maria Costantino Valeria Conti Graziamaria Corbi Amelia Filippelli
author_sort	Maria Costantino
title	Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
title_short	Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
title_full	Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
title_fullStr	Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
title_full_unstemmed	Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life
title_sort	hydropinotherapy with sulphurous mineral water as complementary treatment to improve glucose metabolism, oxidative status, and quality of life
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6c64938c69194dd6b8dd6b31989d14b6
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Hydropinotherapy with Sulphurous Mineral Water as Complementary Treatment to Improve Glucose Metabolism, Oxidative Status, and Quality of Life

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