Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration

Abstract Wilson's Disease (WD), an ATP7B-mutated inherited disease that affects copper transport, is characterised by liver and nervous system manifestations. Long non-coding (ln-c) RNAs are widely involved in almost all physiological and pathological processes in the body, and are associated w...

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Autores principales:	Juan Zhang, Ying Ma, Daojun Xie, Yuancheng Bao, Wenming Yang, Han Wang, Huaizhou Jiang, Hui Han, Ting Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c6518ea8f2244c69bd2c331466cdc66
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spelling	oai:doaj.org-article:6c6518ea8f2244c69bd2c331466cdc662021-12-02T15:22:59ZDifferentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration10.1038/s41598-020-80635-02045-2322https://doaj.org/article/6c6518ea8f2244c69bd2c331466cdc662021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80635-0https://doaj.org/toc/2045-2322Abstract Wilson's Disease (WD), an ATP7B-mutated inherited disease that affects copper transport, is characterised by liver and nervous system manifestations. Long non-coding (ln-c) RNAs are widely involved in almost all physiological and pathological processes in the body, and are associated with numerous diseases. The present study aimed to elucidate the lncRNA-mRNA regulation network in a TX WD mouse model using RNA sequencing (RNA-seq). lncRNA expression profiles were screened using RNA-seq and real-time polymerase chain reaction, and differentially expressed lncRNAs and mRNAs were identified. To analyse the biological functions and pathways for the differentially expressed mRNAs, gene ontology and pathway enrichment analyses were performed. A significantly correlated lncRNA-mRNA relationship pair was calculated by CNC analysis to construct differential lncRNA and mRNA co-expression networks. A total of 2564 significantly up-regulated and 1052 down-regulated lncRNAs, and 1576 up-regulated and 297 down-regulated mRNAs, were identified. These genes were found to be associated with key processes such as apoptosis, and KEGG analysis revealed enrichment in the drug metabolism-cytochrome P450 pathway, PPAR signalling pathway, Notch signalling pathway, and MAPK signalling pathway. The identified differential lncRNAs may be involved in the pathogenesis and development of WD liver injury.Juan ZhangYing MaDaojun XieYuancheng BaoWenming YangHan WangHuaizhou JiangHui HanTing DongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Zhang Ying Ma Daojun Xie Yuancheng Bao Wenming Yang Han Wang Huaizhou Jiang Hui Han Ting Dong Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
description	Abstract Wilson's Disease (WD), an ATP7B-mutated inherited disease that affects copper transport, is characterised by liver and nervous system manifestations. Long non-coding (ln-c) RNAs are widely involved in almost all physiological and pathological processes in the body, and are associated with numerous diseases. The present study aimed to elucidate the lncRNA-mRNA regulation network in a TX WD mouse model using RNA sequencing (RNA-seq). lncRNA expression profiles were screened using RNA-seq and real-time polymerase chain reaction, and differentially expressed lncRNAs and mRNAs were identified. To analyse the biological functions and pathways for the differentially expressed mRNAs, gene ontology and pathway enrichment analyses were performed. A significantly correlated lncRNA-mRNA relationship pair was calculated by CNC analysis to construct differential lncRNA and mRNA co-expression networks. A total of 2564 significantly up-regulated and 1052 down-regulated lncRNAs, and 1576 up-regulated and 297 down-regulated mRNAs, were identified. These genes were found to be associated with key processes such as apoptosis, and KEGG analysis revealed enrichment in the drug metabolism-cytochrome P450 pathway, PPAR signalling pathway, Notch signalling pathway, and MAPK signalling pathway. The identified differential lncRNAs may be involved in the pathogenesis and development of WD liver injury.
format	article
author	Juan Zhang Ying Ma Daojun Xie Yuancheng Bao Wenming Yang Han Wang Huaizhou Jiang Hui Han Ting Dong
author_facet	Juan Zhang Ying Ma Daojun Xie Yuancheng Bao Wenming Yang Han Wang Huaizhou Jiang Hui Han Ting Dong
author_sort	Juan Zhang
title	Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
title_short	Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
title_full	Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
title_fullStr	Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
title_full_unstemmed	Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration
title_sort	differentially expressed lncrnas in liver tissues of tx mice with hepatolenticular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c6518ea8f2244c69bd2c331466cdc66
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_version_	1718387330767650816

Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration

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