Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer

Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis. Nonetheless, the potential roles of 5mC regulators in the tumor microenvironment (TME) remain unclear.Methods: The 5mC modification patterns...

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Autores principales:	Taisheng Liu, Liyi Guo, Guihong Liu, Xiaoshan Hu, Xiaoning Li, Jinye Zhang, Zili Dai, Peng Yu, Ming Jiang, Jian Wang, Jian Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lung adenocarcinoma 5mC tumour microenvironment immunotherapy mutation burden Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6c67763ce29847589ce1ab3e4f76e173
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spelling	oai:doaj.org-article:6c67763ce29847589ce1ab3e4f76e1732021-11-11T07:49:22ZMolecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer2296-634X10.3389/fcell.2021.779367https://doaj.org/article/6c67763ce29847589ce1ab3e4f76e1732021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.779367/fullhttps://doaj.org/toc/2296-634XBackground: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis. Nonetheless, the potential roles of 5mC regulators in the tumor microenvironment (TME) remain unclear.Methods: The 5mC modification patterns of 1,374 lung adenocarcinoma samples were analyzed systematically. The correlation between the 5mC modification and tumor microenvironment cell infiltration was further assessed. The 5mCscore was developed to evaluate tumor mutation burden, immune check-point inhibitor response, and the clinical prognosis of individual tumors.Results: Three 5mC modification patterns were established based on the clinical characteristics of 21 5mC regulators. According to the differential expression of 5mC regulators, three distinct 5mC gene cluster were also identified, which showed distinct TME immune cell infiltration patterns and clinical prognoses. The 5mCscore was constructed to evaluate the tumor mutation burden, immune check-point inhibitor response, and prognosis characteristics. We found that patients with a low 5mCscore had significant immune cell infiltration and increased clinical benefit.Conclusion: This study indicated that the 5mC modification is involved in regulating TME infiltration remodeling. Targeting 5mC modification regulators might be a novel strategy to treat lung cancer.Taisheng LiuLiyi GuoGuihong LiuXiaoshan HuXiaoning LiJinye ZhangZili DaiPeng YuMing JiangJian WangJian ZhangFrontiers Media S.A.articlelung adenocarcinoma5mCtumour microenvironmentimmunotherapymutation burdenBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma 5mC tumour microenvironment immunotherapy mutation burden Biology (General) QH301-705.5
spellingShingle	lung adenocarcinoma 5mC tumour microenvironment immunotherapy mutation burden Biology (General) QH301-705.5 Taisheng Liu Liyi Guo Guihong Liu Xiaoshan Hu Xiaoning Li Jinye Zhang Zili Dai Peng Yu Ming Jiang Jian Wang Jian Zhang Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
description	Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis. Nonetheless, the potential roles of 5mC regulators in the tumor microenvironment (TME) remain unclear.Methods: The 5mC modification patterns of 1,374 lung adenocarcinoma samples were analyzed systematically. The correlation between the 5mC modification and tumor microenvironment cell infiltration was further assessed. The 5mCscore was developed to evaluate tumor mutation burden, immune check-point inhibitor response, and the clinical prognosis of individual tumors.Results: Three 5mC modification patterns were established based on the clinical characteristics of 21 5mC regulators. According to the differential expression of 5mC regulators, three distinct 5mC gene cluster were also identified, which showed distinct TME immune cell infiltration patterns and clinical prognoses. The 5mCscore was constructed to evaluate the tumor mutation burden, immune check-point inhibitor response, and prognosis characteristics. We found that patients with a low 5mCscore had significant immune cell infiltration and increased clinical benefit.Conclusion: This study indicated that the 5mC modification is involved in regulating TME infiltration remodeling. Targeting 5mC modification regulators might be a novel strategy to treat lung cancer.
format	article
author	Taisheng Liu Liyi Guo Guihong Liu Xiaoshan Hu Xiaoning Li Jinye Zhang Zili Dai Peng Yu Ming Jiang Jian Wang Jian Zhang
author_facet	Taisheng Liu Liyi Guo Guihong Liu Xiaoshan Hu Xiaoning Li Jinye Zhang Zili Dai Peng Yu Ming Jiang Jian Wang Jian Zhang
author_sort	Taisheng Liu
title	Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
title_short	Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
title_full	Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
title_fullStr	Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
title_full_unstemmed	Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer
title_sort	molecular characterization of the clinical and tumor immune microenvironment signature of 5-methylcytosine-related regulators in non-small cell lung cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6c67763ce29847589ce1ab3e4f76e173
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Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer

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