Polygenic prediction via Bayesian regression and continuous shrinkage priors

Polygenic prediction via Bayesian regression and continuous shrinkage priors

Polygenic risk scores (PRS) have the potential to predict complex diseases and traits from genetic data. Here, Ge et al. develop PRS-CS which uses a Bayesian regression framework, continuous shrinkage (CS) priors and an external LD reference panel for polygenic prediction of binary and quantitative...

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Autores principales: Tian Ge, Chia-Yen Chen, Yang Ni, Yen-Chen Anne Feng, Jordan W. Smoller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/6c6882b541884b08be03470e789b8afe
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