cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interac...

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Autores principales:	Stefanie Fenske, Konstantin Hennis, René D. Rötzer, Verena F. Brox, Elvir Becirovic, Andreas Scharr, Christian Gruner, Tilman Ziegler, Verena Mehlfeld, Jaclyn Brennan, Igor R. Efimov, Audrys G. Pauža, Markus Moser, Carsten T. Wotjak, Christian Kupatt, Rasmus Gönner, Rai Zhang, Henggui Zhang, Xiangang Zong, Martin Biel, Christian Wahl-Schott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c6af2794e4b4707a82af208feb04493
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spelling	oai:doaj.org-article:6c6af2794e4b4707a82af208feb044932021-12-02T17:32:59ZcAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells10.1038/s41467-020-19304-92041-1723https://doaj.org/article/6c6af2794e4b4707a82af208feb044932020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19304-9https://doaj.org/toc/2041-1723The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interaction between firing and nonfiring pacemaker cells that is controlled by cAMP-dependent regulation of HCN4, with implications in chronotropic heart rate responses.Stefanie FenskeKonstantin HennisRené D. RötzerVerena F. BroxElvir BecirovicAndreas ScharrChristian GrunerTilman ZieglerVerena MehlfeldJaclyn BrennanIgor R. EfimovAudrys G. PaužaMarkus MoserCarsten T. WotjakChristian KupattRasmus GönnerRai ZhangHenggui ZhangXiangang ZongMartin BielChristian Wahl-SchottNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefanie Fenske Konstantin Hennis René D. Rötzer Verena F. Brox Elvir Becirovic Andreas Scharr Christian Gruner Tilman Ziegler Verena Mehlfeld Jaclyn Brennan Igor R. Efimov Audrys G. Pauža Markus Moser Carsten T. Wotjak Christian Kupatt Rasmus Gönner Rai Zhang Henggui Zhang Xiangang Zong Martin Biel Christian Wahl-Schott cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
description	The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interaction between firing and nonfiring pacemaker cells that is controlled by cAMP-dependent regulation of HCN4, with implications in chronotropic heart rate responses.
format	article
author	Stefanie Fenske Konstantin Hennis René D. Rötzer Verena F. Brox Elvir Becirovic Andreas Scharr Christian Gruner Tilman Ziegler Verena Mehlfeld Jaclyn Brennan Igor R. Efimov Audrys G. Pauža Markus Moser Carsten T. Wotjak Christian Kupatt Rasmus Gönner Rai Zhang Henggui Zhang Xiangang Zong Martin Biel Christian Wahl-Schott
author_facet	Stefanie Fenske Konstantin Hennis René D. Rötzer Verena F. Brox Elvir Becirovic Andreas Scharr Christian Gruner Tilman Ziegler Verena Mehlfeld Jaclyn Brennan Igor R. Efimov Audrys G. Pauža Markus Moser Carsten T. Wotjak Christian Kupatt Rasmus Gönner Rai Zhang Henggui Zhang Xiangang Zong Martin Biel Christian Wahl-Schott
author_sort	Stefanie Fenske
title	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
title_short	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
title_full	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
title_fullStr	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
title_full_unstemmed	cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
title_sort	camp-dependent regulation of hcn4 controls the tonic entrainment process in sinoatrial node pacemaker cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c6af2794e4b4707a82af208feb04493
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cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

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