Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degradation in cellular and mouse models of a neuromuscu...

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Autores principales:	Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d95
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spelling	oai:doaj.org-article:6c6c515e273b446cb66da2f55b7b3d952021-12-02T15:35:54ZHsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor10.1038/s41467-019-11594-y2041-1723https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d952019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11594-yhttps://doaj.org/toc/2041-1723Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degradation in cellular and mouse models of a neuromuscular disorder.Bahareh EftekharzadehVaruna C. BanduseelaGiulio ChiesaPaula Martínez-CristóbalJennifer N. RauchSamir R. NathDaniel M. C. SchwarzHao ShaoMarta Marin-ArganyClaudio Di SanzaElisa GiorgettiZhigang YuRoberta PierattelliIsabella C. FelliIsabelle Brun-HeathJesús GarcíaÁngel R. NebredaJason E. GestwickiAndrew P. LiebermanXavier SalvatellaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bahareh Eftekharzadeh Varuna C. Banduseela Giulio Chiesa Paula Martínez-Cristóbal Jennifer N. Rauch Samir R. Nath Daniel M. C. Schwarz Hao Shao Marta Marin-Argany Claudio Di Sanza Elisa Giorgetti Zhigang Yu Roberta Pierattelli Isabella C. Felli Isabelle Brun-Heath Jesús García Ángel R. Nebreda Jason E. Gestwicki Andrew P. Lieberman Xavier Salvatella Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
description	Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degradation in cellular and mouse models of a neuromuscular disorder.
format	article
author	Bahareh Eftekharzadeh Varuna C. Banduseela Giulio Chiesa Paula Martínez-Cristóbal Jennifer N. Rauch Samir R. Nath Daniel M. C. Schwarz Hao Shao Marta Marin-Argany Claudio Di Sanza Elisa Giorgetti Zhigang Yu Roberta Pierattelli Isabella C. Felli Isabelle Brun-Heath Jesús García Ángel R. Nebreda Jason E. Gestwicki Andrew P. Lieberman Xavier Salvatella
author_facet	Bahareh Eftekharzadeh Varuna C. Banduseela Giulio Chiesa Paula Martínez-Cristóbal Jennifer N. Rauch Samir R. Nath Daniel M. C. Schwarz Hao Shao Marta Marin-Argany Claudio Di Sanza Elisa Giorgetti Zhigang Yu Roberta Pierattelli Isabella C. Felli Isabelle Brun-Heath Jesús García Ángel R. Nebreda Jason E. Gestwicki Andrew P. Lieberman Xavier Salvatella
author_sort	Bahareh Eftekharzadeh
title	Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
title_short	Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
title_full	Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
title_fullStr	Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
title_full_unstemmed	Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
title_sort	hsp70 and hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d95
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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor

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