Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.

Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malari...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Owain R Millington, Vivienne B Gibson, Catherine M Rush, Bernd H Zinselmeyer, R Stephen Phillips, Paul Garside, James M Brewer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6c6e1c6e87f9459890b2c00832c88a0b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c6e1c6e87f9459890b2c00832c88a0b
record_format	dspace
spelling	oai:doaj.org-article:6c6e1c6e87f9459890b2c00832c88a0b2021-11-25T05:46:23ZMalaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.1553-73661553-737410.1371/journal.ppat.0030143https://doaj.org/article/6c6e1c6e87f9459890b2c00832c88a0b2007-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.0030143https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.Owain R MillingtonVivienne B GibsonCatherine M RushBernd H ZinselmeyerR Stephen PhillipsPaul GarsideJames M BrewerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 3, Iss 10, Pp 1380-1387 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Owain R Millington Vivienne B Gibson Catherine M Rush Bernd H Zinselmeyer R Stephen Phillips Paul Garside James M Brewer Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
description	Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.
format	article
author	Owain R Millington Vivienne B Gibson Catherine M Rush Bernd H Zinselmeyer R Stephen Phillips Paul Garside James M Brewer
author_facet	Owain R Millington Vivienne B Gibson Catherine M Rush Bernd H Zinselmeyer R Stephen Phillips Paul Garside James M Brewer
author_sort	Owain R Millington
title	Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
title_short	Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
title_full	Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
title_fullStr	Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
title_full_unstemmed	Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.
title_sort	malaria impairs t cell clustering and immune priming despite normal signal 1 from dendritic cells.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/6c6e1c6e87f9459890b2c00832c88a0b
work_keys_str_mv	AT owainrmillington malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT viviennebgibson malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT catherinemrush malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT berndhzinselmeyer malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT rstephenphillips malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT paulgarside malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells AT jamesmbrewer malariaimpairstcellclusteringandimmuneprimingdespitenormalsignal1fromdendriticcells
_version_	1718414461350445056

Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.

Ejemplares similares