Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance.

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Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhibitors varied drastically between these cell lines...

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Detalles Bibliográficos
Autores principales: Mathurin Dorel, Bertram Klinger, Tommaso Mari, Joern Toedling, Eric Blanc, Clemens Messerschmidt, Michal Nadler-Holly, Matthias Ziehm, Anja Sieber, Falk Hertwig, Dieter Beule, Angelika Eggert, Johannes H Schulte, Matthias Selbach, Nils Blüthgen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/6c6e8d855b1e45b79a37ebbd2f6a6b10
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