Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.

Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical net...

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Autores principales:	Daniel Klein, Anna Rotarska-Jagiela, Erhan Genc, Sharmili Sritharan, Harald Mohr, Frederic Roux, Cheol E Han, Marcus Kaiser, Wolf Singer, Peter J Uhlhaas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c77cf3318f84839ab6f093adcfec5c8
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spelling	oai:doaj.org-article:6c77cf3318f84839ab6f093adcfec5c82021-11-18T08:37:44ZAdolescent brain maturation and cortical folding: evidence for reductions in gyrification.1932-620310.1371/journal.pone.0084914https://doaj.org/article/6c77cf3318f84839ab6f093adcfec5c82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24454765/?tool=EBIhttps://doaj.org/toc/1932-6203Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.Daniel KleinAnna Rotarska-JagielaErhan GencSharmili SritharanHarald MohrFrederic RouxCheol E HanMarcus KaiserWolf SingerPeter J UhlhaasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84914 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Klein Anna Rotarska-Jagiela Erhan Genc Sharmili Sritharan Harald Mohr Frederic Roux Cheol E Han Marcus Kaiser Wolf Singer Peter J Uhlhaas Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
description	Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.
format	article
author	Daniel Klein Anna Rotarska-Jagiela Erhan Genc Sharmili Sritharan Harald Mohr Frederic Roux Cheol E Han Marcus Kaiser Wolf Singer Peter J Uhlhaas
author_facet	Daniel Klein Anna Rotarska-Jagiela Erhan Genc Sharmili Sritharan Harald Mohr Frederic Roux Cheol E Han Marcus Kaiser Wolf Singer Peter J Uhlhaas
author_sort	Daniel Klein
title	Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
title_short	Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
title_full	Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
title_fullStr	Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
title_full_unstemmed	Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
title_sort	adolescent brain maturation and cortical folding: evidence for reductions in gyrification.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6c77cf3318f84839ab6f093adcfec5c8
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Adolescent brain maturation and cortical folding: evidence for reductions in gyrification.

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