The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marienela Y. Heredia, Jason M. Rauceo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SPFH prohibitin stomatin mitochondria fungi Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6c7a645f5c544f9abb9eb549c621c72a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c7a645f5c544f9abb9eb549c621c72a
record_format	dspace
spelling	oai:doaj.org-article:6c7a645f5c544f9abb9eb549c621c72a2021-11-25T18:24:51ZThe SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence10.3390/microorganisms91122872076-2607https://doaj.org/article/6c7a645f5c544f9abb9eb549c621c72a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2287https://doaj.org/toc/2076-2607Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling, and mechanosensation. In addition, SPFH proteins are required for virulence in parasites. While mitochondrial functions of SPFH proteins are conserved in fungi, recent evidence has uncovered additional roles for SPFH proteins in filamentation and stress signaling. Inhibitors that target SPFH proteins have been successfully used in cancer and inflammation treatment. Thus, SPFH proteins may serve as a potential target for novel antifungal drug development. This review article surveys SPFH function in various fungal species with a special focus on the most common human fungal pathogen, <i>Candida albicans</i>.Marienela Y. HerediaJason M. RauceoMDPI AGarticleSPFHprohibitinstomatinmitochondriafungiBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2287, p 2287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SPFH prohibitin stomatin mitochondria fungi Biology (General) QH301-705.5
spellingShingle	SPFH prohibitin stomatin mitochondria fungi Biology (General) QH301-705.5 Marienela Y. Heredia Jason M. Rauceo The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
description	Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling, and mechanosensation. In addition, SPFH proteins are required for virulence in parasites. While mitochondrial functions of SPFH proteins are conserved in fungi, recent evidence has uncovered additional roles for SPFH proteins in filamentation and stress signaling. Inhibitors that target SPFH proteins have been successfully used in cancer and inflammation treatment. Thus, SPFH proteins may serve as a potential target for novel antifungal drug development. This review article surveys SPFH function in various fungal species with a special focus on the most common human fungal pathogen, <i>Candida albicans</i>.
format	article
author	Marienela Y. Heredia Jason M. Rauceo
author_facet	Marienela Y. Heredia Jason M. Rauceo
author_sort	Marienela Y. Heredia
title	The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
title_short	The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
title_full	The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
title_fullStr	The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
title_full_unstemmed	The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence
title_sort	spfh protein superfamily in fungi: impact on mitochondrial function and implications in virulence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6c7a645f5c544f9abb9eb549c621c72a
work_keys_str_mv	AT marienelayheredia thespfhproteinsuperfamilyinfungiimpactonmitochondrialfunctionandimplicationsinvirulence AT jasonmrauceo thespfhproteinsuperfamilyinfungiimpactonmitochondrialfunctionandimplicationsinvirulence AT marienelayheredia spfhproteinsuperfamilyinfungiimpactonmitochondrialfunctionandimplicationsinvirulence AT jasonmrauceo spfhproteinsuperfamilyinfungiimpactonmitochondrialfunctionandimplicationsinvirulence
_version_	1718411202105704448

The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Ejemplares similares