T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and...

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Autores principales:	Meng Zhou, Faruk Sacirbegovic, Kai Zhao, Sarah Rosenberger, Warren D. Shlomchik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c7bf027404348d5b25383a3383eaff2
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spelling	oai:doaj.org-article:6c7bf027404348d5b25383a3383eaff22021-12-02T16:35:07ZT cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect10.1038/s41467-020-17991-y2041-1723https://doaj.org/article/6c7bf027404348d5b25383a3383eaff22020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17991-yhttps://doaj.org/toc/2041-1723In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.Meng ZhouFaruk SacirbegovicKai ZhaoSarah RosenbergerWarren D. ShlomchikNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Zhou Faruk Sacirbegovic Kai Zhao Sarah Rosenberger Warren D. Shlomchik T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
description	In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.
format	article
author	Meng Zhou Faruk Sacirbegovic Kai Zhao Sarah Rosenberger Warren D. Shlomchik
author_facet	Meng Zhou Faruk Sacirbegovic Kai Zhao Sarah Rosenberger Warren D. Shlomchik
author_sort	Meng Zhou
title	T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
title_short	T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
title_full	T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
title_fullStr	T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
title_full_unstemmed	T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
title_sort	t cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c7bf027404348d5b25383a3383eaff2
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T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

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