T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and...

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Autores principales: Meng Zhou, Faruk Sacirbegovic, Kai Zhao, Sarah Rosenberger, Warren D. Shlomchik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6c7bf027404348d5b25383a3383eaff2
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