Enhanced validation of antibodies for research applications

Five validation pillars have been proposed to verify the specificity of research antibodies. Here the authors screen 6,000 antibodies from the Human Protein Atlas with these methods to provide an antibody validation resource for providers and users.

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Autores principales:	Fredrik Edfors, Andreas Hober, Klas Linderbäck, Gianluca Maddalo, Alireza Azimi, Åsa Sivertsson, Hanna Tegel, Sophia Hober, Cristina Al-Khalili Szigyarto, Linn Fagerberg, Kalle von Feilitzen, Per Oksvold, Cecilia Lindskog, Björn Forsström, Mathias Uhlen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c7d2dad78f143629130766c264377a4
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spelling	oai:doaj.org-article:6c7d2dad78f143629130766c264377a42021-12-02T14:39:27ZEnhanced validation of antibodies for research applications10.1038/s41467-018-06642-y2041-1723https://doaj.org/article/6c7d2dad78f143629130766c264377a42018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06642-yhttps://doaj.org/toc/2041-1723Five validation pillars have been proposed to verify the specificity of research antibodies. Here the authors screen 6,000 antibodies from the Human Protein Atlas with these methods to provide an antibody validation resource for providers and users.Fredrik EdforsAndreas HoberKlas LinderbäckGianluca MaddaloAlireza AzimiÅsa SivertssonHanna TegelSophia HoberCristina Al-Khalili SzigyartoLinn FagerbergKalle von FeilitzenPer OksvoldCecilia LindskogBjörn ForsströmMathias UhlenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fredrik Edfors Andreas Hober Klas Linderbäck Gianluca Maddalo Alireza Azimi Åsa Sivertsson Hanna Tegel Sophia Hober Cristina Al-Khalili Szigyarto Linn Fagerberg Kalle von Feilitzen Per Oksvold Cecilia Lindskog Björn Forsström Mathias Uhlen Enhanced validation of antibodies for research applications
description	Five validation pillars have been proposed to verify the specificity of research antibodies. Here the authors screen 6,000 antibodies from the Human Protein Atlas with these methods to provide an antibody validation resource for providers and users.
format	article
author	Fredrik Edfors Andreas Hober Klas Linderbäck Gianluca Maddalo Alireza Azimi Åsa Sivertsson Hanna Tegel Sophia Hober Cristina Al-Khalili Szigyarto Linn Fagerberg Kalle von Feilitzen Per Oksvold Cecilia Lindskog Björn Forsström Mathias Uhlen
author_facet	Fredrik Edfors Andreas Hober Klas Linderbäck Gianluca Maddalo Alireza Azimi Åsa Sivertsson Hanna Tegel Sophia Hober Cristina Al-Khalili Szigyarto Linn Fagerberg Kalle von Feilitzen Per Oksvold Cecilia Lindskog Björn Forsström Mathias Uhlen
author_sort	Fredrik Edfors
title	Enhanced validation of antibodies for research applications
title_short	Enhanced validation of antibodies for research applications
title_full	Enhanced validation of antibodies for research applications
title_fullStr	Enhanced validation of antibodies for research applications
title_full_unstemmed	Enhanced validation of antibodies for research applications
title_sort	enhanced validation of antibodies for research applications
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6c7d2dad78f143629130766c264377a4
work_keys_str_mv	AT fredrikedfors enhancedvalidationofantibodiesforresearchapplications AT andreashober enhancedvalidationofantibodiesforresearchapplications AT klaslinderback enhancedvalidationofantibodiesforresearchapplications AT gianlucamaddalo enhancedvalidationofantibodiesforresearchapplications AT alirezaazimi enhancedvalidationofantibodiesforresearchapplications AT asasivertsson enhancedvalidationofantibodiesforresearchapplications AT hannategel enhancedvalidationofantibodiesforresearchapplications AT sophiahober enhancedvalidationofantibodiesforresearchapplications AT cristinaalkhaliliszigyarto enhancedvalidationofantibodiesforresearchapplications AT linnfagerberg enhancedvalidationofantibodiesforresearchapplications AT kallevonfeilitzen enhancedvalidationofantibodiesforresearchapplications AT peroksvold enhancedvalidationofantibodiesforresearchapplications AT cecilialindskog enhancedvalidationofantibodiesforresearchapplications AT bjornforsstrom enhancedvalidationofantibodiesforresearchapplications AT mathiasuhlen enhancedvalidationofantibodiesforresearchapplications
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Enhanced validation of antibodies for research applications

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