The mitotic spindle is chiral due to torques within microtubule bundles

Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 induce chirality and curves into the spindle.

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Autores principales:	Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae20
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spelling	oai:doaj.org-article:6c7f670a0f214d33b19b8f2d1e62ae202021-12-02T16:49:51ZThe mitotic spindle is chiral due to torques within microtubule bundles10.1038/s41467-018-06005-72041-1723https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae202018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06005-7https://doaj.org/toc/2041-1723Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 induce chirality and curves into the spindle.Maja NovakBruno PolakJuraj SimunićZvonimir BobanBarbara KuzmićAndreas W. ThomaeIva M. TolićNenad PavinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maja Novak Bruno Polak Juraj Simunić Zvonimir Boban Barbara Kuzmić Andreas W. Thomae Iva M. Tolić Nenad Pavin The mitotic spindle is chiral due to torques within microtubule bundles
description	Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 induce chirality and curves into the spindle.
format	article
author	Maja Novak Bruno Polak Juraj Simunić Zvonimir Boban Barbara Kuzmić Andreas W. Thomae Iva M. Tolić Nenad Pavin
author_facet	Maja Novak Bruno Polak Juraj Simunić Zvonimir Boban Barbara Kuzmić Andreas W. Thomae Iva M. Tolić Nenad Pavin
author_sort	Maja Novak
title	The mitotic spindle is chiral due to torques within microtubule bundles
title_short	The mitotic spindle is chiral due to torques within microtubule bundles
title_full	The mitotic spindle is chiral due to torques within microtubule bundles
title_fullStr	The mitotic spindle is chiral due to torques within microtubule bundles
title_full_unstemmed	The mitotic spindle is chiral due to torques within microtubule bundles
title_sort	mitotic spindle is chiral due to torques within microtubule bundles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae20
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The mitotic spindle is chiral due to torques within microtubule bundles

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