The mitotic spindle is chiral due to torques within microtubule bundles

Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 induce chirality and curves into the spindle.

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Detalles Bibliográficos
Autores principales: Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae20
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