Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.

Age-related changes in autobiographical memory (AM) recall are characterized by a decline in episodic details, while semantic aspects are spared. This deleterious effect is supposed to be mediated by an inefficient recruitment of executive processes during AM retrieval. To date, contrasting evidence...

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Autores principales:	Pénélope Martinelli, Marco Sperduti, Anne-Dominique Devauchelle, Sandrine Kalenzaga, Thierry Gallarda, Stéphanie Lion, Marion Delhommeau, Adèle Anssens, Isabelle Amado, Jean François Meder, Marie-Odile Krebs, Catherine Oppenheim, Pascale Piolino
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c847393a27247de9fc00c983db7593c
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spelling	oai:doaj.org-article:6c847393a27247de9fc00c983db7593c2021-11-18T08:41:24ZAge-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.1932-620310.1371/journal.pone.0082385https://doaj.org/article/6c847393a27247de9fc00c983db7593c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367516/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Age-related changes in autobiographical memory (AM) recall are characterized by a decline in episodic details, while semantic aspects are spared. This deleterious effect is supposed to be mediated by an inefficient recruitment of executive processes during AM retrieval. To date, contrasting evidence has been reported on the neural underpinning of this decline, and none of the previous studies has directly compared the episodic and semantic aspects of AM in elderly. We asked 20 young and 17 older participants to recall specific and general autobiographical events (i.e., episodic and semantic AM) elicited by personalized cues while recording their brain activity by means of fMRI. At the behavioral level, we confirmed that the richness of episodic AM retrieval is specifically impoverished in aging and that this decline is related to the reduction of executive functions. At the neural level, in both age groups, we showed the recruitment of a large network during episodic AM retrieval encompassing prefrontal, cortical midline and posterior regions, and medial temporal structures, including the hippocampus. This network was very similar, but less extended, during semantic AM retrieval. Nevertheless, a greater activity was evidenced in the dorsal anterior cingulate cortex (dACC) during episodic, compared to semantic AM retrieval in young participants, and a reversed pattern in the elderly. Moreover, activity in dACC during episodic AM retrieval was correlated with inhibition and richness of memories in both groups. Our findings shed light on the direct link between episodic AM retrieval, executive control, and their decline in aging, proposing a possible neuronal signature. They also suggest that increased activity in dACC during semantic AM retrieval in the elderly could be seen as a compensatory mechanism underpinning successful AM performance observed in aging. These results are discussed in the framework of recently proposed models of neural reorganization in aging.Pénélope MartinelliMarco SperdutiAnne-Dominique DevauchelleSandrine KalenzagaThierry GallardaStéphanie LionMarion DelhommeauAdèle AnssensIsabelle AmadoJean François MederMarie-Odile KrebsCatherine OppenheimPascale PiolinoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82385 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pénélope Martinelli Marco Sperduti Anne-Dominique Devauchelle Sandrine Kalenzaga Thierry Gallarda Stéphanie Lion Marion Delhommeau Adèle Anssens Isabelle Amado Jean François Meder Marie-Odile Krebs Catherine Oppenheim Pascale Piolino Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
description	Age-related changes in autobiographical memory (AM) recall are characterized by a decline in episodic details, while semantic aspects are spared. This deleterious effect is supposed to be mediated by an inefficient recruitment of executive processes during AM retrieval. To date, contrasting evidence has been reported on the neural underpinning of this decline, and none of the previous studies has directly compared the episodic and semantic aspects of AM in elderly. We asked 20 young and 17 older participants to recall specific and general autobiographical events (i.e., episodic and semantic AM) elicited by personalized cues while recording their brain activity by means of fMRI. At the behavioral level, we confirmed that the richness of episodic AM retrieval is specifically impoverished in aging and that this decline is related to the reduction of executive functions. At the neural level, in both age groups, we showed the recruitment of a large network during episodic AM retrieval encompassing prefrontal, cortical midline and posterior regions, and medial temporal structures, including the hippocampus. This network was very similar, but less extended, during semantic AM retrieval. Nevertheless, a greater activity was evidenced in the dorsal anterior cingulate cortex (dACC) during episodic, compared to semantic AM retrieval in young participants, and a reversed pattern in the elderly. Moreover, activity in dACC during episodic AM retrieval was correlated with inhibition and richness of memories in both groups. Our findings shed light on the direct link between episodic AM retrieval, executive control, and their decline in aging, proposing a possible neuronal signature. They also suggest that increased activity in dACC during semantic AM retrieval in the elderly could be seen as a compensatory mechanism underpinning successful AM performance observed in aging. These results are discussed in the framework of recently proposed models of neural reorganization in aging.
format	article
author	Pénélope Martinelli Marco Sperduti Anne-Dominique Devauchelle Sandrine Kalenzaga Thierry Gallarda Stéphanie Lion Marion Delhommeau Adèle Anssens Isabelle Amado Jean François Meder Marie-Odile Krebs Catherine Oppenheim Pascale Piolino
author_facet	Pénélope Martinelli Marco Sperduti Anne-Dominique Devauchelle Sandrine Kalenzaga Thierry Gallarda Stéphanie Lion Marion Delhommeau Adèle Anssens Isabelle Amado Jean François Meder Marie-Odile Krebs Catherine Oppenheim Pascale Piolino
author_sort	Pénélope Martinelli
title	Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
title_short	Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
title_full	Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
title_fullStr	Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
title_full_unstemmed	Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
title_sort	age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6c847393a27247de9fc00c983db7593c
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Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex.

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