Clinical Implications of Thrombocytopenia for the Cirrhotic Patient

Samuel H Sigal,1 Zachary Sherman,2 Arun Jesudian2 1Department of Medicine, Montefiore Medical Center, Bronx, NY, USA; 2Department of Medicine, Weill Cornell Medical Center, New York, NY, USACorrespondence: Samuel H SigalMontefiore Medical Center, Bronx, NY 10467 Tel +1 718 920-6240Fax +1917 398-8466...

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Autores principales:	Sigal SH, Sherman Z, Jesudian A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	thrombocytopenia prognosis invasive procedures liver regeneration Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/6c86ee4e67dc41f79bfae1ad373a2894
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spelling	oai:doaj.org-article:6c86ee4e67dc41f79bfae1ad373a28942021-12-02T04:07:47ZClinical Implications of Thrombocytopenia for the Cirrhotic Patient1179-1535https://doaj.org/article/6c86ee4e67dc41f79bfae1ad373a28942020-04-01T00:00:00Zhttps://www.dovepress.com/clinical-implications-of-thrombocytopenia-for-the-cirrhotic-patient-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Samuel H Sigal,1 Zachary Sherman,2 Arun Jesudian2 1Department of Medicine, Montefiore Medical Center, Bronx, NY, USA; 2Department of Medicine, Weill Cornell Medical Center, New York, NY, USACorrespondence: Samuel H SigalMontefiore Medical Center, Bronx, NY 10467 Tel +1 718 920-6240Fax +1917 398-8466Email ssigal@montefiore.orgAbstract: Thrombocytopenia is a frequent complication in patients with cirrhosis. As many as 84% of patients with cirrhosis have thrombocytopenia, and it is an independent variable indicative of advanced disease and poor prognosis. Although there is great concern that it may aggravate bleeding during surgical procedures, there is limited evidence to inform decisions regarding the treatment of cirrhotic patients with thrombocytopenia undergoing invasive procedures. Finally, there is evidence that platelets play a significant role in liver regeneration. In this report, the clinical implications of thrombocytopenia in cirrhotic patients are reviewed. The utility of platelet counts in the prognosis of cirrhosis and relationship to complications of advanced liver disease, including portal hypertension, esophageal varices, and hepatocellular carcinoma. The impact of low platelet counts on bleeding complications during invasive procedures is outlined. Finally, the role of platelets and potential adverse impact in liver regeneration is reviewed.Keywords: thrombocytopenia, prognosis, invasive procedures, liver regenerationSigal SHSherman ZJesudian ADove Medical Pressarticlethrombocytopeniaprognosisinvasive proceduresliver regenerationDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 12, Pp 49-60 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	thrombocytopenia prognosis invasive procedures liver regeneration Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	thrombocytopenia prognosis invasive procedures liver regeneration Diseases of the digestive system. Gastroenterology RC799-869 Sigal SH Sherman Z Jesudian A Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
description	Samuel H Sigal,1 Zachary Sherman,2 Arun Jesudian2 1Department of Medicine, Montefiore Medical Center, Bronx, NY, USA; 2Department of Medicine, Weill Cornell Medical Center, New York, NY, USACorrespondence: Samuel H SigalMontefiore Medical Center, Bronx, NY 10467 Tel +1 718 920-6240Fax +1917 398-8466Email ssigal@montefiore.orgAbstract: Thrombocytopenia is a frequent complication in patients with cirrhosis. As many as 84% of patients with cirrhosis have thrombocytopenia, and it is an independent variable indicative of advanced disease and poor prognosis. Although there is great concern that it may aggravate bleeding during surgical procedures, there is limited evidence to inform decisions regarding the treatment of cirrhotic patients with thrombocytopenia undergoing invasive procedures. Finally, there is evidence that platelets play a significant role in liver regeneration. In this report, the clinical implications of thrombocytopenia in cirrhotic patients are reviewed. The utility of platelet counts in the prognosis of cirrhosis and relationship to complications of advanced liver disease, including portal hypertension, esophageal varices, and hepatocellular carcinoma. The impact of low platelet counts on bleeding complications during invasive procedures is outlined. Finally, the role of platelets and potential adverse impact in liver regeneration is reviewed.Keywords: thrombocytopenia, prognosis, invasive procedures, liver regeneration
format	article
author	Sigal SH Sherman Z Jesudian A
author_facet	Sigal SH Sherman Z Jesudian A
author_sort	Sigal SH
title	Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
title_short	Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
title_full	Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
title_fullStr	Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
title_full_unstemmed	Clinical Implications of Thrombocytopenia for the Cirrhotic Patient
title_sort	clinical implications of thrombocytopenia for the cirrhotic patient
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6c86ee4e67dc41f79bfae1ad373a2894
work_keys_str_mv	AT sigalsh clinicalimplicationsofthrombocytopeniaforthecirrhoticpatient AT shermanz clinicalimplicationsofthrombocytopeniaforthecirrhoticpatient AT jesudiana clinicalimplicationsofthrombocytopeniaforthecirrhoticpatient
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Clinical Implications of Thrombocytopenia for the Cirrhotic Patient

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