Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.

West Nile virus (WNV) is a neurovirulent single stranded RNA mosquito-borne flavivirus, whose main natural hosts are birds, but it also infects humans and horses. Nowadays, no human vaccine is commercially available and clinical treatment is only supportive. Recently, it has been shown that RNA tran...

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Autores principales:	Miguel Rodríguez-Pulido, Miguel A Martín-Acebes, Estela Escribano-Romero, Ana-Belén Blázquez, Francisco Sobrino, Belén Borrego, Margarita Sáiz, Juan-Carlos Saiz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c8a1c760ebc48398c96b4300cb2aa78
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spelling	oai:doaj.org-article:6c8a1c760ebc48398c96b4300cb2aa782021-11-18T08:08:43ZProtection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.1932-620310.1371/journal.pone.0049494https://doaj.org/article/6c8a1c760ebc48398c96b4300cb2aa782012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166685/?tool=EBIhttps://doaj.org/toc/1932-6203West Nile virus (WNV) is a neurovirulent single stranded RNA mosquito-borne flavivirus, whose main natural hosts are birds, but it also infects humans and horses. Nowadays, no human vaccine is commercially available and clinical treatment is only supportive. Recently, it has been shown that RNA transcripts, mimicking structural domains in the non-coding regions (NCRs) of the foot-and mouth disease virus (FMDV) induce a potent IFN response and antiviral activity in transfected cultured cells, and also reduced mice susceptibility to FMDV. By using different transcripts combinations, administration schedules, and infecting routes and doses, we have demonstrated that these FMDV RNA transcripts protect suckling and adult mice against lethal challenge with WNV. The protective activity induced by the transcripts was systemic and dependent on the infection route and dose. These results confirm the antiviral potential of these synthetic RNAs for fighting viruses of different families relevant for human and animal health.Miguel Rodríguez-PulidoMiguel A Martín-AcebesEstela Escribano-RomeroAna-Belén BlázquezFrancisco SobrinoBelén BorregoMargarita SáizJuan-Carlos SaizPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49494 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miguel Rodríguez-Pulido Miguel A Martín-Acebes Estela Escribano-Romero Ana-Belén Blázquez Francisco Sobrino Belén Borrego Margarita Sáiz Juan-Carlos Saiz Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
description	West Nile virus (WNV) is a neurovirulent single stranded RNA mosquito-borne flavivirus, whose main natural hosts are birds, but it also infects humans and horses. Nowadays, no human vaccine is commercially available and clinical treatment is only supportive. Recently, it has been shown that RNA transcripts, mimicking structural domains in the non-coding regions (NCRs) of the foot-and mouth disease virus (FMDV) induce a potent IFN response and antiviral activity in transfected cultured cells, and also reduced mice susceptibility to FMDV. By using different transcripts combinations, administration schedules, and infecting routes and doses, we have demonstrated that these FMDV RNA transcripts protect suckling and adult mice against lethal challenge with WNV. The protective activity induced by the transcripts was systemic and dependent on the infection route and dose. These results confirm the antiviral potential of these synthetic RNAs for fighting viruses of different families relevant for human and animal health.
format	article
author	Miguel Rodríguez-Pulido Miguel A Martín-Acebes Estela Escribano-Romero Ana-Belén Blázquez Francisco Sobrino Belén Borrego Margarita Sáiz Juan-Carlos Saiz
author_facet	Miguel Rodríguez-Pulido Miguel A Martín-Acebes Estela Escribano-Romero Ana-Belén Blázquez Francisco Sobrino Belén Borrego Margarita Sáiz Juan-Carlos Saiz
author_sort	Miguel Rodríguez-Pulido
title	Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
title_short	Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
title_full	Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
title_fullStr	Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
title_full_unstemmed	Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.
title_sort	protection against west nile virus infection in mice after inoculation with type i interferon-inducing rna transcripts.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6c8a1c760ebc48398c96b4300cb2aa78
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Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.

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