Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell comp...

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Main Authors: Jan Krivanek, Ruslan A. Soldatov, Maria Eleni Kastriti, Tatiana Chontorotzea, Anna Nele Herdina, Julian Petersen, Bara Szarowska, Marie Landova, Veronika Kovar Matejova, Lydie Izakovicova Holla, Ulrike Kuchler, Ivana Vidovic Zdrilic, Anushree Vijaykumar, Anamaria Balic, Pauline Marangoni, Ophir D. Klein, Vitor C. M. Neves, Val Yianni, Paul T. Sharpe, Tibor Harkany, Brian D. Metscher, Marc Bajénoff, Mina Mina, Kaj Fried, Peter V. Kharchenko, Igor Adameyko
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/6c8df9e45ced47ac834d40d04694da4c
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Summary:Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.

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