Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation

During preimplantation development, a wave of genome-wide DNA demethylation occurs to acquire a hypomethylated genome of the blastocyst. As an essential epigenomic event, postfertilization DNA demethylation is critical to establish full developmental potential. Despite its importance, this process i...

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Auteurs principaux: Meiqiang Chu, Fusheng Yao, Guangyin Xi, Jiajun Yang, Zhenni Zhang, Qianying Yang, Jianhui Tian, Lei An
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
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Accès en ligne:https://doaj.org/article/6c8f70886f2043cd9f51ea6d8eb3d7d2
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