Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle

Abstract To understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil should be considered in addition to the initial radiation directly received from the bombs. 56Mn, which emits both β particles and γ-...

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Autores principales:	Nariaki Fujimoto, Bakhyt Ruslanova, Zhaslan Abishev, Nailya Chaizhunussova, Dariya Shabdarbayeva, Gaukhar Amantayeva, Rakhimzhanova Farida, Marat Sandybayev, Kasuke Nagano, Kassym Zhumadilov, Andrey Kaprin, Sergey Ivanov, Valeriy Stepanenko, Masaharu Hoshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c907f0146a3428286195f331ed688ac
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spelling	oai:doaj.org-article:6c907f0146a3428286195f331ed688ac2021-12-02T14:49:17ZBiological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle10.1038/s41598-021-90443-92045-2322https://doaj.org/article/6c907f0146a3428286195f331ed688ac2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90443-9https://doaj.org/toc/2045-2322Abstract To understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil should be considered in addition to the initial radiation directly received from the bombs. 56Mn, which emits both β particles and γ-rays, is one of the dominant radioisotopes created in soil by neutrons from the bomb. Thus we investigated the biological effects of internal exposure to 56MnO2 particle in the lung of male Wistar rats comparing to the effects of external 60Co-γ irradiation. Absorbed doses of internal irradiation of lungs were between 25 and 65 mGy in 56MnO2-exposed animals, while the whole body doses were between 41 and 100 mGy. Animals were examined on days 3 and 61 after the exposure. There were no remarkable pathological changes related to 56MnO2 particle exposure. However, mRNA and protein expressions of aquaporin 5 increased significantly in the lung tissue on day 3 postexposure in 56MnO2 groups (by 1.6 and 2.9 times, respectively, in the highest dose group). Smad7 mRNA expression was also significantly elevated by 30% in the highest dose group of 56MnO2. Our data demonstrated that internal exposure to 56MnO2 induced significant biological responses including gene expression changes in the lungs, while external 60Co-γ irradiation of 2 Gy did not show any changes.Nariaki FujimotoBakhyt RuslanovaZhaslan AbishevNailya ChaizhunussovaDariya ShabdarbayevaGaukhar AmantayevaRakhimzhanova FaridaMarat SandybayevKasuke NaganoKassym ZhumadilovAndrey KaprinSergey IvanovValeriy StepanenkoMasaharu HoshiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nariaki Fujimoto Bakhyt Ruslanova Zhaslan Abishev Nailya Chaizhunussova Dariya Shabdarbayeva Gaukhar Amantayeva Rakhimzhanova Farida Marat Sandybayev Kasuke Nagano Kassym Zhumadilov Andrey Kaprin Sergey Ivanov Valeriy Stepanenko Masaharu Hoshi Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
description	Abstract To understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil should be considered in addition to the initial radiation directly received from the bombs. 56Mn, which emits both β particles and γ-rays, is one of the dominant radioisotopes created in soil by neutrons from the bomb. Thus we investigated the biological effects of internal exposure to 56MnO2 particle in the lung of male Wistar rats comparing to the effects of external 60Co-γ irradiation. Absorbed doses of internal irradiation of lungs were between 25 and 65 mGy in 56MnO2-exposed animals, while the whole body doses were between 41 and 100 mGy. Animals were examined on days 3 and 61 after the exposure. There were no remarkable pathological changes related to 56MnO2 particle exposure. However, mRNA and protein expressions of aquaporin 5 increased significantly in the lung tissue on day 3 postexposure in 56MnO2 groups (by 1.6 and 2.9 times, respectively, in the highest dose group). Smad7 mRNA expression was also significantly elevated by 30% in the highest dose group of 56MnO2. Our data demonstrated that internal exposure to 56MnO2 induced significant biological responses including gene expression changes in the lungs, while external 60Co-γ irradiation of 2 Gy did not show any changes.
format	article
author	Nariaki Fujimoto Bakhyt Ruslanova Zhaslan Abishev Nailya Chaizhunussova Dariya Shabdarbayeva Gaukhar Amantayeva Rakhimzhanova Farida Marat Sandybayev Kasuke Nagano Kassym Zhumadilov Andrey Kaprin Sergey Ivanov Valeriy Stepanenko Masaharu Hoshi
author_facet	Nariaki Fujimoto Bakhyt Ruslanova Zhaslan Abishev Nailya Chaizhunussova Dariya Shabdarbayeva Gaukhar Amantayeva Rakhimzhanova Farida Marat Sandybayev Kasuke Nagano Kassym Zhumadilov Andrey Kaprin Sergey Ivanov Valeriy Stepanenko Masaharu Hoshi
author_sort	Nariaki Fujimoto
title	Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
title_short	Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
title_full	Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
title_fullStr	Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
title_full_unstemmed	Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
title_sort	biological impacts on the lungs in rats internally exposed to radioactive 56mno2 particle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c907f0146a3428286195f331ed688ac
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Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle

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