Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.

Interactions between environmental factors and predisposing genes could be involved in the development of coeliac disease (CD). This study has assessed whether milk-feeding type and HLA-genotype influence the intestinal microbiota composition of infants with a family history of CD. The study include...

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Autores principales:	Giada De Palma, Amalia Capilla, Esther Nova, Gemma Castillejo, Vicente Varea, Tamara Pozo, José Antonio Garrote, Isabel Polanco, Ana López, Carmen Ribes-Koninckx, Ascensión Marcos, María Dolores García-Novo, Carmen Calvo, Luis Ortigosa, Luis Peña-Quintana, Francesc Palau, Yolanda Sanz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c994cace60b4af887f57c8434f287e2
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spelling	oai:doaj.org-article:6c994cace60b4af887f57c8434f287e22021-11-18T07:28:54ZInfluence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.1932-620310.1371/journal.pone.0030791https://doaj.org/article/6c994cace60b4af887f57c8434f287e22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319588/?tool=EBIhttps://doaj.org/toc/1932-6203Interactions between environmental factors and predisposing genes could be involved in the development of coeliac disease (CD). This study has assessed whether milk-feeding type and HLA-genotype influence the intestinal microbiota composition of infants with a family history of CD. The study included 164 healthy newborns, with at least one first-degree relative with CD, classified according to their HLA-DQ genotype by PCR-SSP DQB1 and DQA1 typing. Faecal microbiota was analysed by quantitative PCR at 7 days, and at 1 and 4 months of age. Significant interactions between milk-feeding type and HLA-DQ genotype on bacterial numbers were not detected by applying a linear mixed-model analysis for repeated measures. In the whole population, breast-feeding promoted colonization of C. leptum group, B. longum and B. breve, while formula-feeding promoted that of Bacteroides fragilis group, C. coccoides-E. rectale group, E. coli and B. lactis. Moreover, increased numbers of B. fragilis group and Staphylococcus spp., and reduced numbers of Bifidobacterium spp. and B. longum were detected in infants with increased genetic risk of developing CD. Analyses within subgroups of either breast-fed or formula-fed infants indicated that in both cases increased risk of CD was associated with lower numbers of B. longum and/or Bifidobacterium spp. In addition, in breast-fed infants the increased genetic risk of developing CD was associated with increased C. leptum group numbers, while in formula-fed infants it was associated with increased Staphylococcus and B. fragilis group numbers. Overall, milk-feeding type in conjunction with HLA-DQ genotype play a role in establishing infants' gut microbiota; moreover, breast-feeding reduced the genotype-related differences in microbiota composition, which could partly explain the protective role attributed to breast milk in this disorder.Giada De PalmaAmalia CapillaEsther NovaGemma CastillejoVicente VareaTamara PozoJosé Antonio GarroteIsabel PolancoAna LópezCarmen Ribes-KoninckxAscensión MarcosMaría Dolores García-NovoCarmen CalvoLuis OrtigosaLuis Peña-QuintanaFrancesc PalauYolanda SanzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e30791 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giada De Palma Amalia Capilla Esther Nova Gemma Castillejo Vicente Varea Tamara Pozo José Antonio Garrote Isabel Polanco Ana López Carmen Ribes-Koninckx Ascensión Marcos María Dolores García-Novo Carmen Calvo Luis Ortigosa Luis Peña-Quintana Francesc Palau Yolanda Sanz Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
description	Interactions between environmental factors and predisposing genes could be involved in the development of coeliac disease (CD). This study has assessed whether milk-feeding type and HLA-genotype influence the intestinal microbiota composition of infants with a family history of CD. The study included 164 healthy newborns, with at least one first-degree relative with CD, classified according to their HLA-DQ genotype by PCR-SSP DQB1 and DQA1 typing. Faecal microbiota was analysed by quantitative PCR at 7 days, and at 1 and 4 months of age. Significant interactions between milk-feeding type and HLA-DQ genotype on bacterial numbers were not detected by applying a linear mixed-model analysis for repeated measures. In the whole population, breast-feeding promoted colonization of C. leptum group, B. longum and B. breve, while formula-feeding promoted that of Bacteroides fragilis group, C. coccoides-E. rectale group, E. coli and B. lactis. Moreover, increased numbers of B. fragilis group and Staphylococcus spp., and reduced numbers of Bifidobacterium spp. and B. longum were detected in infants with increased genetic risk of developing CD. Analyses within subgroups of either breast-fed or formula-fed infants indicated that in both cases increased risk of CD was associated with lower numbers of B. longum and/or Bifidobacterium spp. In addition, in breast-fed infants the increased genetic risk of developing CD was associated with increased C. leptum group numbers, while in formula-fed infants it was associated with increased Staphylococcus and B. fragilis group numbers. Overall, milk-feeding type in conjunction with HLA-DQ genotype play a role in establishing infants' gut microbiota; moreover, breast-feeding reduced the genotype-related differences in microbiota composition, which could partly explain the protective role attributed to breast milk in this disorder.
format	article
author	Giada De Palma Amalia Capilla Esther Nova Gemma Castillejo Vicente Varea Tamara Pozo José Antonio Garrote Isabel Polanco Ana López Carmen Ribes-Koninckx Ascensión Marcos María Dolores García-Novo Carmen Calvo Luis Ortigosa Luis Peña-Quintana Francesc Palau Yolanda Sanz
author_facet	Giada De Palma Amalia Capilla Esther Nova Gemma Castillejo Vicente Varea Tamara Pozo José Antonio Garrote Isabel Polanco Ana López Carmen Ribes-Koninckx Ascensión Marcos María Dolores García-Novo Carmen Calvo Luis Ortigosa Luis Peña-Quintana Francesc Palau Yolanda Sanz
author_sort	Giada De Palma
title	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
title_short	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
title_full	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
title_fullStr	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
title_full_unstemmed	Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.
title_sort	influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the proficel study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6c994cace60b4af887f57c8434f287e2
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Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study.

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