Importin α7 is essential for zygotic genome activation and early mouse development.

Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early e...

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Autores principales:	Franziska Rother, Tatiana Shmidt, Elena Popova, Alexander Krivokharchenko, Stefanie Hügel, Larissa Vilianovich, Michael Ridders, Katja Tenner, Natalia Alenina, Matthias Köhler, Enno Hartmann, Michael Bader
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c9b4ff2639348929863a2005d307b1a
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id	oai:doaj.org-article:6c9b4ff2639348929863a2005d307b1a
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spelling	oai:doaj.org-article:6c9b4ff2639348929863a2005d307b1a2021-11-18T06:56:37ZImportin α7 is essential for zygotic genome activation and early mouse development.1932-620310.1371/journal.pone.0018310https://doaj.org/article/6c9b4ff2639348929863a2005d307b1a2011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21479251/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.Franziska RotherTatiana ShmidtElena PopovaAlexander KrivokharchenkoStefanie HügelLarissa VilianovichMichael RiddersKatja TennerNatalia AleninaMatthias KöhlerEnno HartmannMichael BaderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18310 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Franziska Rother Tatiana Shmidt Elena Popova Alexander Krivokharchenko Stefanie Hügel Larissa Vilianovich Michael Ridders Katja Tenner Natalia Alenina Matthias Köhler Enno Hartmann Michael Bader Importin α7 is essential for zygotic genome activation and early mouse development.
description	Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.
format	article
author	Franziska Rother Tatiana Shmidt Elena Popova Alexander Krivokharchenko Stefanie Hügel Larissa Vilianovich Michael Ridders Katja Tenner Natalia Alenina Matthias Köhler Enno Hartmann Michael Bader
author_facet	Franziska Rother Tatiana Shmidt Elena Popova Alexander Krivokharchenko Stefanie Hügel Larissa Vilianovich Michael Ridders Katja Tenner Natalia Alenina Matthias Köhler Enno Hartmann Michael Bader
author_sort	Franziska Rother
title	Importin α7 is essential for zygotic genome activation and early mouse development.
title_short	Importin α7 is essential for zygotic genome activation and early mouse development.
title_full	Importin α7 is essential for zygotic genome activation and early mouse development.
title_fullStr	Importin α7 is essential for zygotic genome activation and early mouse development.
title_full_unstemmed	Importin α7 is essential for zygotic genome activation and early mouse development.
title_sort	importin α7 is essential for zygotic genome activation and early mouse development.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6c9b4ff2639348929863a2005d307b1a
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Importin α7 is essential for zygotic genome activation and early mouse development.

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