Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

ABSTRACT Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, these patients often receive prophylactic systemic antimicrobial therapy. Intriguingly however, a previous study showed that antimicrobial activity in bronchoalveolar aspirates (here referred to as “sputa”) fr...

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Autores principales: Jolien Seinen, Rudolf Engelke, Mohammed R. Abdullah, Franziska Voß, Stephan Michalik, Vishnu M. Dhople, Willem Dieperink, Anne Marie G. A. de Smet, Uwe Völker, Jan Maarten van Dijl, Frank Schmidt, Sven Hammerschmidt
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Streptococcus pneumoniae
mechanical ventilation
sputum
antimicrobial peptides
immunoproteomics
proteomics
Microbiology
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Acceso en línea:https://doaj.org/article/6c9f6b805eed4bd5ae06bb19ef52b18c
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