Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

ABSTRACT Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, these patients often receive prophylactic systemic antimicrobial therapy. Intriguingly however, a previous study showed that antimicrobial activity in bronchoalveolar aspirates (here referred to as “sputa”) fr...

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Bibliographic Details
Main Authors: Jolien Seinen, Rudolf Engelke, Mohammed R. Abdullah, Franziska Voß, Stephan Michalik, Vishnu M. Dhople, Willem Dieperink, Anne Marie G. A. de Smet, Uwe Völker, Jan Maarten van Dijl, Frank Schmidt, Sven Hammerschmidt
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Streptococcus pneumoniae
mechanical ventilation
sputum
antimicrobial peptides
immunoproteomics
proteomics
Microbiology
QR1-502
Online Access:https://doaj.org/article/6c9f6b805eed4bd5ae06bb19ef52b18c
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