Metastasis inhibition in breast cancer by targeting cancer cell extravasation

Márcia R Cominetti,1 Wanessa F Altei,2 Heloisa Sobreiro Selistre-de-Araujo21Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil; 2Department of Physiological Sciences, Federal University of São Carlos, São Carlos,...

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Autores principales:	Cominetti MR, Altei WF, Selistre-de-Araujo HS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	breast cancer metastasis extravasation circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6c9f73a41793480bbf2e6078d951378d
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spelling	oai:doaj.org-article:6c9f73a41793480bbf2e6078d951378d2021-12-02T06:31:18ZMetastasis inhibition in breast cancer by targeting cancer cell extravasation1179-1314https://doaj.org/article/6c9f73a41793480bbf2e6078d951378d2019-04-01T00:00:00Zhttps://www.dovepress.com/metastasis-inhibition-in-breast-cancer-by-targeting-cancer-cell-extrav-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Márcia R Cominetti,1 Wanessa F Altei,2 Heloisa Sobreiro Selistre-de-Araujo21Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil; 2Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, BrazilAbstract: The spread of cells from primary tumors toward distant tissues and organs, also known as metastasis, is responsible for most cancer-associated deaths. The metastasis cascade comprises a series of events, characterized by the displacement of tumor cells (TCs) from the primary tumor to distant organs by traveling through the bloodstream, and their subsequent colonization. The first step in metastasis involves loss of cell-cell and cell-matrix adhesions, increased invasiveness and migratory abilities, leading to intravasation of TCs into the blood or lymphatic vessels. Stationary TCs must undergo the process of epithelial-mesenchymal transition in order to achieve this migratory and invasive phenotype. Circulating tumor cells that have survived in the circulation and left the blood or lymphatic vessels will reach distant sites where they may stay dormant for many years or grow to form secondary tumors. To do this, cells need to go through the mesenchymal-epithelial transition to revert the phenotype in order to regain epithelial cell-to-cell junctions, grow and become a clinically relevant and detectable tumor mass. This work will review the main steps of the metastatic cascade and describe some strategies to inhibit metastasis by reducing cancer cell extravasation presenting recent studies in the context of breast cancer.Keywords: breast cancer, metastasis, extravasation, circulating tumor cellsCominetti MRAltei WFSelistre-de-Araujo HSDove Medical Pressarticlebreast cancermetastasisextravasationcirculating tumor cellsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 11, Pp 165-178 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer metastasis extravasation circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer metastasis extravasation circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cominetti MR Altei WF Selistre-de-Araujo HS Metastasis inhibition in breast cancer by targeting cancer cell extravasation
description	Márcia R Cominetti,1 Wanessa F Altei,2 Heloisa Sobreiro Selistre-de-Araujo21Department of Gerontology, Federal University of São Carlos, São Carlos, SP, Brazil; 2Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, BrazilAbstract: The spread of cells from primary tumors toward distant tissues and organs, also known as metastasis, is responsible for most cancer-associated deaths. The metastasis cascade comprises a series of events, characterized by the displacement of tumor cells (TCs) from the primary tumor to distant organs by traveling through the bloodstream, and their subsequent colonization. The first step in metastasis involves loss of cell-cell and cell-matrix adhesions, increased invasiveness and migratory abilities, leading to intravasation of TCs into the blood or lymphatic vessels. Stationary TCs must undergo the process of epithelial-mesenchymal transition in order to achieve this migratory and invasive phenotype. Circulating tumor cells that have survived in the circulation and left the blood or lymphatic vessels will reach distant sites where they may stay dormant for many years or grow to form secondary tumors. To do this, cells need to go through the mesenchymal-epithelial transition to revert the phenotype in order to regain epithelial cell-to-cell junctions, grow and become a clinically relevant and detectable tumor mass. This work will review the main steps of the metastatic cascade and describe some strategies to inhibit metastasis by reducing cancer cell extravasation presenting recent studies in the context of breast cancer.Keywords: breast cancer, metastasis, extravasation, circulating tumor cells
format	article
author	Cominetti MR Altei WF Selistre-de-Araujo HS
author_facet	Cominetti MR Altei WF Selistre-de-Araujo HS
author_sort	Cominetti MR
title	Metastasis inhibition in breast cancer by targeting cancer cell extravasation
title_short	Metastasis inhibition in breast cancer by targeting cancer cell extravasation
title_full	Metastasis inhibition in breast cancer by targeting cancer cell extravasation
title_fullStr	Metastasis inhibition in breast cancer by targeting cancer cell extravasation
title_full_unstemmed	Metastasis inhibition in breast cancer by targeting cancer cell extravasation
title_sort	metastasis inhibition in breast cancer by targeting cancer cell extravasation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6c9f73a41793480bbf2e6078d951378d
work_keys_str_mv	AT cominettimr metastasisinhibitioninbreastcancerbytargetingcancercellextravasation AT alteiwf metastasisinhibitioninbreastcancerbytargetingcancercellextravasation AT selistredearaujohs metastasisinhibitioninbreastcancerbytargetingcancercellextravasation
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Metastasis inhibition in breast cancer by targeting cancer cell extravasation

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