A two-stage meta-analysis identifies several new loci for Parkinson's disease.

A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on...

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Autores principales:	International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6c9feae05d8f41afaedef0dc8f93ad36
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spelling	oai:doaj.org-article:6c9feae05d8f41afaedef0dc8f93ad362021-11-18T06:17:16ZA two-stage meta-analysis identifies several new loci for Parkinson's disease.1553-73901553-740410.1371/journal.pgen.1002142https://doaj.org/article/6c9feae05d8f41afaedef0dc8f93ad362011-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738488/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p<5×10(-10), PARK16/1q32, STX1B/16p11, FGF20/8p22, STBD1/4q21, and GPNMB/7p15). Two of these five loci have been suggested by previous association studies (PARK16/1q32, FGF20/8p22), and this study provides further support for these findings. Using a dataset of post-mortem brain samples assayed for gene expression (n = 399) and methylation (n = 292), we identified methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci, hence suggesting potential molecular mechanisms and candidate genes at these risk loci.International Parkinson's Disease Genomics Consortium (IPDGC)Wellcome Trust Case Control Consortium 2 (WTCCC2)Public Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 7, Iss 6, p e1002142 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 International Parkinson's Disease Genomics Consortium (IPDGC) Wellcome Trust Case Control Consortium 2 (WTCCC2) A two-stage meta-analysis identifies several new loci for Parkinson's disease.
description	A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p<5×10(-10), PARK16/1q32, STX1B/16p11, FGF20/8p22, STBD1/4q21, and GPNMB/7p15). Two of these five loci have been suggested by previous association studies (PARK16/1q32, FGF20/8p22), and this study provides further support for these findings. Using a dataset of post-mortem brain samples assayed for gene expression (n = 399) and methylation (n = 292), we identified methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci, hence suggesting potential molecular mechanisms and candidate genes at these risk loci.
format	article
author	International Parkinson's Disease Genomics Consortium (IPDGC) Wellcome Trust Case Control Consortium 2 (WTCCC2)
author_facet	International Parkinson's Disease Genomics Consortium (IPDGC) Wellcome Trust Case Control Consortium 2 (WTCCC2)
author_sort	International Parkinson's Disease Genomics Consortium (IPDGC)
title	A two-stage meta-analysis identifies several new loci for Parkinson's disease.
title_short	A two-stage meta-analysis identifies several new loci for Parkinson's disease.
title_full	A two-stage meta-analysis identifies several new loci for Parkinson's disease.
title_fullStr	A two-stage meta-analysis identifies several new loci for Parkinson's disease.
title_full_unstemmed	A two-stage meta-analysis identifies several new loci for Parkinson's disease.
title_sort	two-stage meta-analysis identifies several new loci for parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6c9feae05d8f41afaedef0dc8f93ad36
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A two-stage meta-analysis identifies several new loci for Parkinson's disease.

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