Natural biased coin encoded in the genome determines cell strategy.

Decision making at a cellular level determines different fates for isogenic cells. However, it is not yet clear how rational decisions are encoded in the genome, how they are transmitted to their offspring, and whether they evolve and become optimized throughout generations. In this paper, we use a...

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Autores principales:	Faezeh Dorri, Hamid Mahini, Ali Sharifi-Zarchi, Mehdi Totonchi, Ruzbeh Tusserkani, Hamid Pezeshk, Mehdi Sadeghi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ca1ff0e973647d88e94eb0701faebf9
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id	oai:doaj.org-article:6ca1ff0e973647d88e94eb0701faebf9
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spelling	oai:doaj.org-article:6ca1ff0e973647d88e94eb0701faebf92021-11-25T06:06:14ZNatural biased coin encoded in the genome determines cell strategy.1932-620310.1371/journal.pone.0103569https://doaj.org/article/6ca1ff0e973647d88e94eb0701faebf92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25090629/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Decision making at a cellular level determines different fates for isogenic cells. However, it is not yet clear how rational decisions are encoded in the genome, how they are transmitted to their offspring, and whether they evolve and become optimized throughout generations. In this paper, we use a game theoretic approach to explain how rational decisions are made in the presence of cooperators and competitors. Our results suggest the existence of an internal switch that operates as a biased coin. The biased coin is, in fact, a biochemical bistable network of interacting genes that can flip to one of its stable states in response to different environmental stimuli. We present a framework to describe how the positions of attractors in such a gene regulatory network correspond to the behavior of a rational player in a competing environment. We evaluate our model by considering lysis/lysogeny decision making of bacteriophage lambda in E. coli.Faezeh DorriHamid MahiniAli Sharifi-ZarchiMehdi TotonchiRuzbeh TusserkaniHamid PezeshkMehdi SadeghiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103569 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faezeh Dorri Hamid Mahini Ali Sharifi-Zarchi Mehdi Totonchi Ruzbeh Tusserkani Hamid Pezeshk Mehdi Sadeghi Natural biased coin encoded in the genome determines cell strategy.
description	Decision making at a cellular level determines different fates for isogenic cells. However, it is not yet clear how rational decisions are encoded in the genome, how they are transmitted to their offspring, and whether they evolve and become optimized throughout generations. In this paper, we use a game theoretic approach to explain how rational decisions are made in the presence of cooperators and competitors. Our results suggest the existence of an internal switch that operates as a biased coin. The biased coin is, in fact, a biochemical bistable network of interacting genes that can flip to one of its stable states in response to different environmental stimuli. We present a framework to describe how the positions of attractors in such a gene regulatory network correspond to the behavior of a rational player in a competing environment. We evaluate our model by considering lysis/lysogeny decision making of bacteriophage lambda in E. coli.
format	article
author	Faezeh Dorri Hamid Mahini Ali Sharifi-Zarchi Mehdi Totonchi Ruzbeh Tusserkani Hamid Pezeshk Mehdi Sadeghi
author_facet	Faezeh Dorri Hamid Mahini Ali Sharifi-Zarchi Mehdi Totonchi Ruzbeh Tusserkani Hamid Pezeshk Mehdi Sadeghi
author_sort	Faezeh Dorri
title	Natural biased coin encoded in the genome determines cell strategy.
title_short	Natural biased coin encoded in the genome determines cell strategy.
title_full	Natural biased coin encoded in the genome determines cell strategy.
title_fullStr	Natural biased coin encoded in the genome determines cell strategy.
title_full_unstemmed	Natural biased coin encoded in the genome determines cell strategy.
title_sort	natural biased coin encoded in the genome determines cell strategy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6ca1ff0e973647d88e94eb0701faebf9
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_version_	1718414168888967168

Natural biased coin encoded in the genome determines cell strategy.

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