Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis

Background: Triglyceride glycemic (TyG) index is a novel tool for assessing insulin resistance (IR). Recently, TyG index as a potential biomarker f or gestational diabetes mellitus (GDM) has been studied, but its performance is yet inc onclusive. Thus, we performed this systemic review and meta-anal...

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Autores principales:	Yusen Liu, Ruiwen Chi, Yujie Jiang, Bicheng Chen, Youli Chen, Zengrui Chen
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	gestational diabetes mellitus triglyceride glycemic index meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doi.org/10.1530/EC-21-0234 https://doaj.org/article/6ca216d8aa134faca537b436d2e6be1b
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spelling	oai:doaj.org-article:6ca216d8aa134faca537b436d2e6be1b2021-11-10T12:02:41ZTriglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysishttps://doi.org/10.1530/EC-21-02342049-3614https://doaj.org/article/6ca216d8aa134faca537b436d2e6be1b2021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0234.xmlhttps://doaj.org/toc/2049-3614Background: Triglyceride glycemic (TyG) index is a novel tool for assessing insulin resistance (IR). Recently, TyG index as a potential biomarker f or gestational diabetes mellitus (GDM) has been studied, but its performance is yet inc onclusive. Thus, we performed this systemic review and meta-analysis to evaluate th e performance of TyG index in predicting GDM. Methods: Studies published before March 1, 2021, with comparison of TyG index between GDM patients and healthy controls were retrieved from multiple databases (PubMed, Web of Science, The Cochrane Library, and Embase). The mean diff erence (MD) of TyG index in GDM patients and healthy controls was pooled using ran dom-effect models. Results: Differentiation of TyG index between patients with GDM and cont rols showed significant results. Overall, there is a four-fold increase in T yG index in GDM patients compared with controls (MD: 0.22, 95% CI: 0.07–0.36, P = 0.003; I2 = 71%, P = 0.009). In subgroup analyses according to gestational time, TyG index in t he second trimester predicted GDM with low heterogeneity (MD: 0.26, 95% CI: 0.15–0. 37, P < 0.001; I2 = 0%, P = 0.54), while no such correlation was found in the first trimest er. Conclusion: TyG index, especially in the second trimester, could be a prom ising biomarker for predicting GDM. Yusen LiuRuiwen ChiYujie JiangBicheng ChenYouli ChenZengrui ChenBioscientificaarticlegestational diabetes mellitustriglyceride glycemic indexmeta-analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1420-1427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestational diabetes mellitus triglyceride glycemic index meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	gestational diabetes mellitus triglyceride glycemic index meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yusen Liu Ruiwen Chi Yujie Jiang Bicheng Chen Youli Chen Zengrui Chen Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
description	Background: Triglyceride glycemic (TyG) index is a novel tool for assessing insulin resistance (IR). Recently, TyG index as a potential biomarker f or gestational diabetes mellitus (GDM) has been studied, but its performance is yet inc onclusive. Thus, we performed this systemic review and meta-analysis to evaluate th e performance of TyG index in predicting GDM. Methods: Studies published before March 1, 2021, with comparison of TyG index between GDM patients and healthy controls were retrieved from multiple databases (PubMed, Web of Science, The Cochrane Library, and Embase). The mean diff erence (MD) of TyG index in GDM patients and healthy controls was pooled using ran dom-effect models. Results: Differentiation of TyG index between patients with GDM and cont rols showed significant results. Overall, there is a four-fold increase in T yG index in GDM patients compared with controls (MD: 0.22, 95% CI: 0.07–0.36, P = 0.003; I2 = 71%, P = 0.009). In subgroup analyses according to gestational time, TyG index in t he second trimester predicted GDM with low heterogeneity (MD: 0.26, 95% CI: 0.15–0. 37, P < 0.001; I2 = 0%, P = 0.54), while no such correlation was found in the first trimest er. Conclusion: TyG index, especially in the second trimester, could be a prom ising biomarker for predicting GDM.
format	article
author	Yusen Liu Ruiwen Chi Yujie Jiang Bicheng Chen Youli Chen Zengrui Chen
author_facet	Yusen Liu Ruiwen Chi Yujie Jiang Bicheng Chen Youli Chen Zengrui Chen
author_sort	Yusen Liu
title	Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
title_short	Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
title_full	Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
title_fullStr	Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
title_full_unstemmed	Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
title_sort	triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/EC-21-0234 https://doaj.org/article/6ca216d8aa134faca537b436d2e6be1b
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Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis

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