Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Low frequency coding single-nucleotide variants (SNVs) are predicted to disproportionately affect protein function. Here, the authors evaluate 2,009 missense SNVs across 2,185 protein-protein interactions using yeast two-hybrid and protein complementation assays and find that disruptive SNVs often o...

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Autores principales:	Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546
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spelling	oai:doaj.org-article:6ca43b750ead45778c9bbf8306bf15462021-12-02T16:58:04ZExtensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations10.1038/s41467-019-11959-32041-1723https://doaj.org/article/6ca43b750ead45778c9bbf8306bf15462019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11959-3https://doaj.org/toc/2041-1723Low frequency coding single-nucleotide variants (SNVs) are predicted to disproportionately affect protein function. Here, the authors evaluate 2,009 missense SNVs across 2,185 protein-protein interactions using yeast two-hybrid and protein complementation assays and find that disruptive SNVs often occur in disease-associated genes.Robert FragozaJishnu DasShayne D. WierbowskiJin LiangTina N. TranSiqi LiangJuan F. BeltranChristen A. Rivera-ErickKaixiong YeTing-Yi WangLi YaoMatthew MortPeter D. StensonDavid N. CooperXiaomu WeiAlon KeinanJohn C. SchimentiAndrew G. ClarkHaiyuan YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert Fragoza Jishnu Das Shayne D. Wierbowski Jin Liang Tina N. Tran Siqi Liang Juan F. Beltran Christen A. Rivera-Erick Kaixiong Ye Ting-Yi Wang Li Yao Matthew Mort Peter D. Stenson David N. Cooper Xiaomu Wei Alon Keinan John C. Schimenti Andrew G. Clark Haiyuan Yu Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
description	Low frequency coding single-nucleotide variants (SNVs) are predicted to disproportionately affect protein function. Here, the authors evaluate 2,009 missense SNVs across 2,185 protein-protein interactions using yeast two-hybrid and protein complementation assays and find that disruptive SNVs often occur in disease-associated genes.
format	article
author	Robert Fragoza Jishnu Das Shayne D. Wierbowski Jin Liang Tina N. Tran Siqi Liang Juan F. Beltran Christen A. Rivera-Erick Kaixiong Ye Ting-Yi Wang Li Yao Matthew Mort Peter D. Stenson David N. Cooper Xiaomu Wei Alon Keinan John C. Schimenti Andrew G. Clark Haiyuan Yu
author_facet	Robert Fragoza Jishnu Das Shayne D. Wierbowski Jin Liang Tina N. Tran Siqi Liang Juan F. Beltran Christen A. Rivera-Erick Kaixiong Ye Ting-Yi Wang Li Yao Matthew Mort Peter D. Stenson David N. Cooper Xiaomu Wei Alon Keinan John C. Schimenti Andrew G. Clark Haiyuan Yu
author_sort	Robert Fragoza
title	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
title_short	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
title_full	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
title_fullStr	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
title_full_unstemmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
title_sort	extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546
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Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

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