Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

Abstract Polycystic ovary syndrome (PCOS) is a global health concern for women of reproductive age, as 6.5% of women worldwide are affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals such as arsenic, cadmium, lead and me...

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Autores principales:	Manal Abudawood, Hajera Tabassum, Atheer H. Alanazi, Fatmah Almusallam, Feda Aljaser, Mir Naiman Ali, Naif D. Alenzi, Samyah T. Alanazi, Manal A. Alghamdi, Ghadah H. Altoum, Manar A. Alzeer, Majed O. Alotaibi, Arwa Abudawood, Hazem K. Ghneim, Lulu Abdullah Ali Al-Nuaim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ca64565436342698c66bf9e238dec99
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spelling	oai:doaj.org-article:6ca64565436342698c66bf9e238dec992021-11-28T12:21:50ZAntioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)10.1038/s41598-021-02120-62045-2322https://doaj.org/article/6ca64565436342698c66bf9e238dec992021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02120-6https://doaj.org/toc/2045-2322Abstract Polycystic ovary syndrome (PCOS) is a global health concern for women of reproductive age, as 6.5% of women worldwide are affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals such as arsenic, cadmium, lead and mercury are considered to be systemic toxicants/human carcinogens and seem to have devastating effects on humans, even at minimal exposures. One of the probable aetiological factors for PCOS has been identified as oxidative stress. In view of the probable associations among oxidative stress, metal toxicity and PCOS, the present study examined the role of heavy metals in the generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50 women who were not diagnosed with PCOS as control women). There were no significant differences in the sociodemographic characteristics between the two groups except for the irregularity of menses and the presence of acne. The serum As, Cd, Pb, and Hg levels increased and the serum glutathione (GSH) and superoxide dismutase (SOD) levels diminished significantly in the PCOS group compared to the control group at P < 0.001. The SOD levels were negatively correlated with the As and Pb levels at P < 0.05. Additionally, the PCOS group exhibited a strong negative correlation between the GSH and As levels (P < 0.01), GSH and Pb levels (P < 0.05) and GSH and Hg levels (P < 0.01). Furthermore, the As levels were positively correlated with increased levels of Cd, Pb and Hg among PCOS women. Significant positive correlations were observed between Pb and Cd and between Cd and Hg at P < 0.001. The outcome of the study provides clear insight into the role of metal-induced oxidative stress, which plays a vital role in the pathophysiology underlying PCOS and suggests the use of these markers as prognostic tools to reduce the consequences of high-risk exposure to these metals among females.Manal AbudawoodHajera TabassumAtheer H. AlanaziFatmah AlmusallamFeda AljaserMir Naiman AliNaif D. AlenziSamyah T. AlanaziManal A. AlghamdiGhadah H. AltoumManar A. AlzeerMajed O. AlotaibiArwa AbudawoodHazem K. GhneimLulu Abdullah Ali Al-NuaimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manal Abudawood Hajera Tabassum Atheer H. Alanazi Fatmah Almusallam Feda Aljaser Mir Naiman Ali Naif D. Alenzi Samyah T. Alanazi Manal A. Alghamdi Ghadah H. Altoum Manar A. Alzeer Majed O. Alotaibi Arwa Abudawood Hazem K. Ghneim Lulu Abdullah Ali Al-Nuaim Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
description	Abstract Polycystic ovary syndrome (PCOS) is a global health concern for women of reproductive age, as 6.5% of women worldwide are affected by this syndrome. PCOS is marked by hyperandrogenism, anovulation, menstrual abnormalities, and polycystic ovaries. Metals such as arsenic, cadmium, lead and mercury are considered to be systemic toxicants/human carcinogens and seem to have devastating effects on humans, even at minimal exposures. One of the probable aetiological factors for PCOS has been identified as oxidative stress. In view of the probable associations among oxidative stress, metal toxicity and PCOS, the present study examined the role of heavy metals in the generation of oxidative stress among females. This prospective study included 106 women (56 women diagnosed with PCOS and 50 women who were not diagnosed with PCOS as control women). There were no significant differences in the sociodemographic characteristics between the two groups except for the irregularity of menses and the presence of acne. The serum As, Cd, Pb, and Hg levels increased and the serum glutathione (GSH) and superoxide dismutase (SOD) levels diminished significantly in the PCOS group compared to the control group at P < 0.001. The SOD levels were negatively correlated with the As and Pb levels at P < 0.05. Additionally, the PCOS group exhibited a strong negative correlation between the GSH and As levels (P < 0.01), GSH and Pb levels (P < 0.05) and GSH and Hg levels (P < 0.01). Furthermore, the As levels were positively correlated with increased levels of Cd, Pb and Hg among PCOS women. Significant positive correlations were observed between Pb and Cd and between Cd and Hg at P < 0.001. The outcome of the study provides clear insight into the role of metal-induced oxidative stress, which plays a vital role in the pathophysiology underlying PCOS and suggests the use of these markers as prognostic tools to reduce the consequences of high-risk exposure to these metals among females.
format	article
author	Manal Abudawood Hajera Tabassum Atheer H. Alanazi Fatmah Almusallam Feda Aljaser Mir Naiman Ali Naif D. Alenzi Samyah T. Alanazi Manal A. Alghamdi Ghadah H. Altoum Manar A. Alzeer Majed O. Alotaibi Arwa Abudawood Hazem K. Ghneim Lulu Abdullah Ali Al-Nuaim
author_facet	Manal Abudawood Hajera Tabassum Atheer H. Alanazi Fatmah Almusallam Feda Aljaser Mir Naiman Ali Naif D. Alenzi Samyah T. Alanazi Manal A. Alghamdi Ghadah H. Altoum Manar A. Alzeer Majed O. Alotaibi Arwa Abudawood Hazem K. Ghneim Lulu Abdullah Ali Al-Nuaim
author_sort	Manal Abudawood
title	Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
title_short	Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
title_full	Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
title_fullStr	Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
title_full_unstemmed	Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
title_sort	antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (pcos)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6ca64565436342698c66bf9e238dec99
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Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

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