Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques
Zika virus (ZIKV) infection in pregnant women has been associated with fetal developmental defects. Here, the authors show that a Brazilian ZIKV isolate causes fetal demise in non-human primates and that antibody treatment at time of peak viremia is insufficient to clear ZIKV replication from amniot...
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Nature Portfolio
2018
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oai:doaj.org-article:6ca8c5f99d854de99a13b95f4edccb072021-12-02T14:40:03ZFetal demise and failed antibody therapy during Zika virus infection of pregnant macaques10.1038/s41467-018-04056-42041-1723https://doaj.org/article/6ca8c5f99d854de99a13b95f4edccb072018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04056-4https://doaj.org/toc/2041-1723Zika virus (ZIKV) infection in pregnant women has been associated with fetal developmental defects. Here, the authors show that a Brazilian ZIKV isolate causes fetal demise in non-human primates and that antibody treatment at time of peak viremia is insufficient to clear ZIKV replication from amniotic fluid.Diogo M. MagnaniThomas F. RogersNicholas J. ManessNathan D. GrubaughNathan BeutlerVarian K. BaileyLucas Gonzalez-NietoMartin J. GutmanNúria Pedreño-LopezJaclyn M. KwalMichael J. RicciardiTereance A. MyersJustin G. JulanderRudolf P. BohmMargaret H. GilbertFaith SchiroPyone P. AyeRobert V. BlairMauricio A. MartinsKathrine P. FalkensteinAmitinder KaurChristine L. CurryEsper G. KallasRonald C. DesrosiersPascal J. Goldschmidt-ClermontStephen S. WhiteheadKristian G. AndersenMyrna C. BonaldoAndrew A. LacknerAntonito T. PanganibanDennis R. BurtonDavid I. WatkinsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Diogo M. Magnani Thomas F. Rogers Nicholas J. Maness Nathan D. Grubaugh Nathan Beutler Varian K. Bailey Lucas Gonzalez-Nieto Martin J. Gutman Núria Pedreño-Lopez Jaclyn M. Kwal Michael J. Ricciardi Tereance A. Myers Justin G. Julander Rudolf P. Bohm Margaret H. Gilbert Faith Schiro Pyone P. Aye Robert V. Blair Mauricio A. Martins Kathrine P. Falkenstein Amitinder Kaur Christine L. Curry Esper G. Kallas Ronald C. Desrosiers Pascal J. Goldschmidt-Clermont Stephen S. Whitehead Kristian G. Andersen Myrna C. Bonaldo Andrew A. Lackner Antonito T. Panganiban Dennis R. Burton David I. Watkins Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| description |
Zika virus (ZIKV) infection in pregnant women has been associated with fetal developmental defects. Here, the authors show that a Brazilian ZIKV isolate causes fetal demise in non-human primates and that antibody treatment at time of peak viremia is insufficient to clear ZIKV replication from amniotic fluid. |
| format |
article |
| author |
Diogo M. Magnani Thomas F. Rogers Nicholas J. Maness Nathan D. Grubaugh Nathan Beutler Varian K. Bailey Lucas Gonzalez-Nieto Martin J. Gutman Núria Pedreño-Lopez Jaclyn M. Kwal Michael J. Ricciardi Tereance A. Myers Justin G. Julander Rudolf P. Bohm Margaret H. Gilbert Faith Schiro Pyone P. Aye Robert V. Blair Mauricio A. Martins Kathrine P. Falkenstein Amitinder Kaur Christine L. Curry Esper G. Kallas Ronald C. Desrosiers Pascal J. Goldschmidt-Clermont Stephen S. Whitehead Kristian G. Andersen Myrna C. Bonaldo Andrew A. Lackner Antonito T. Panganiban Dennis R. Burton David I. Watkins |
| author_facet |
Diogo M. Magnani Thomas F. Rogers Nicholas J. Maness Nathan D. Grubaugh Nathan Beutler Varian K. Bailey Lucas Gonzalez-Nieto Martin J. Gutman Núria Pedreño-Lopez Jaclyn M. Kwal Michael J. Ricciardi Tereance A. Myers Justin G. Julander Rudolf P. Bohm Margaret H. Gilbert Faith Schiro Pyone P. Aye Robert V. Blair Mauricio A. Martins Kathrine P. Falkenstein Amitinder Kaur Christine L. Curry Esper G. Kallas Ronald C. Desrosiers Pascal J. Goldschmidt-Clermont Stephen S. Whitehead Kristian G. Andersen Myrna C. Bonaldo Andrew A. Lackner Antonito T. Panganiban Dennis R. Burton David I. Watkins |
| author_sort |
Diogo M. Magnani |
| title |
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| title_short |
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| title_full |
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| title_fullStr |
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| title_full_unstemmed |
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques |
| title_sort |
fetal demise and failed antibody therapy during zika virus infection of pregnant macaques |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/6ca8c5f99d854de99a13b95f4edccb07 |
| work_keys_str_mv |
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1718390420475478016 |