Tackling obesity: new therapeutic agents for assisted weight loss

JG Karam1, SI McFarlane21SUNY-Downstate-Kings County Hospital, Brooklyn, NY, USA, Maimonides Medical Center, Brooklyn, NY, USA; 2Division of Endocrinology, College of Medicine, State University of New York-Downstate Medical Center, New York, USAAbstract: The pandemic of overweight and obesity contin...

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Autores principales:	JG Karam, SI McFarlane
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6caafee8754645bda5a905ded7a7d8d5
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spelling	oai:doaj.org-article:6caafee8754645bda5a905ded7a7d8d52021-12-02T01:00:10ZTackling obesity: new therapeutic agents for assisted weight loss1178-7007https://doaj.org/article/6caafee8754645bda5a905ded7a7d8d52010-04-01T00:00:00Zhttp://www.dovepress.com/tackling-obesity-new-therapeutic-agents-for-assisted-weight-loss-a4313https://doaj.org/toc/1178-7007JG Karam1, SI McFarlane21SUNY-Downstate-Kings County Hospital, Brooklyn, NY, USA, Maimonides Medical Center, Brooklyn, NY, USA; 2Division of Endocrinology, College of Medicine, State University of New York-Downstate Medical Center, New York, USAAbstract: The pandemic of overweight and obesity continues to rise in an alarming rate in western countries and around the globe representing a major public health challenge in desperate need for new strategies tackling obesity. In the United States nearly two thirds of the population is overweight or obese. Worldwide the number of persons who are overweight or obese exceeded 1.6 billion. These rising figures have been clearly associated with increased morbidity and mortality. For example, in the Framingham study, the risk of death increases with each additional pound of weight gain even in the relatively younger population between 30 and 42 years of age. Overweight and obesity are also associated with increased co-morbid conditions such as diabetes, hypertension and cardiovascular disease as well as certain types of cancer. In this review we discuss the epidemic of obesity, highlighting the pathophysiologic mechanisms of weight gain. We also provide an overview of the assessment of overweight and obese individuals discussing possible secondary causes of obesity. In a detailed section we discuss the currently approved therapeutic interventions for obesity highlighting their mechanisms of action and evidence of their efficacy and safety as provided in clinical trials. Finally, we discuss novel therapeutic interventions that are in various stages of development with a special section on the weight loss effects of anti-diabetic medications. These agents are particularly attractive options for our growing population of obese diabetic individuals.Keywords: obesity, assisted weight loss, therapy JG KaramSI McFarlaneDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 95-112 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 JG Karam SI McFarlane Tackling obesity: new therapeutic agents for assisted weight loss
description	JG Karam1, SI McFarlane21SUNY-Downstate-Kings County Hospital, Brooklyn, NY, USA, Maimonides Medical Center, Brooklyn, NY, USA; 2Division of Endocrinology, College of Medicine, State University of New York-Downstate Medical Center, New York, USAAbstract: The pandemic of overweight and obesity continues to rise in an alarming rate in western countries and around the globe representing a major public health challenge in desperate need for new strategies tackling obesity. In the United States nearly two thirds of the population is overweight or obese. Worldwide the number of persons who are overweight or obese exceeded 1.6 billion. These rising figures have been clearly associated with increased morbidity and mortality. For example, in the Framingham study, the risk of death increases with each additional pound of weight gain even in the relatively younger population between 30 and 42 years of age. Overweight and obesity are also associated with increased co-morbid conditions such as diabetes, hypertension and cardiovascular disease as well as certain types of cancer. In this review we discuss the epidemic of obesity, highlighting the pathophysiologic mechanisms of weight gain. We also provide an overview of the assessment of overweight and obese individuals discussing possible secondary causes of obesity. In a detailed section we discuss the currently approved therapeutic interventions for obesity highlighting their mechanisms of action and evidence of their efficacy and safety as provided in clinical trials. Finally, we discuss novel therapeutic interventions that are in various stages of development with a special section on the weight loss effects of anti-diabetic medications. These agents are particularly attractive options for our growing population of obese diabetic individuals.Keywords: obesity, assisted weight loss, therapy
format	article
author	JG Karam SI McFarlane
author_facet	JG Karam SI McFarlane
author_sort	JG Karam
title	Tackling obesity: new therapeutic agents for assisted weight loss
title_short	Tackling obesity: new therapeutic agents for assisted weight loss
title_full	Tackling obesity: new therapeutic agents for assisted weight loss
title_fullStr	Tackling obesity: new therapeutic agents for assisted weight loss
title_full_unstemmed	Tackling obesity: new therapeutic agents for assisted weight loss
title_sort	tackling obesity: new therapeutic agents for assisted weight loss
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/6caafee8754645bda5a905ded7a7d8d5
work_keys_str_mv	AT jgkaram tacklingobesitynewtherapeuticagentsforassistedweightloss AT simcfarlane tacklingobesitynewtherapeuticagentsforassistedweightloss
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Tackling obesity: new therapeutic agents for assisted weight loss

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