Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice

Abstract In this study we demonstrate that 2 month old APPswe/PS1dE9 mice, a transgenic model of Alzheimer’s disease, exhibited intact short-term memory in Pavlovian hippocampal—dependent contextual fear learning task. However, their long-term memory was impaired. Intra-CA1 infusion of isoproterenol...

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Autor principal:	Smitha Karunakaran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cac17ed878a4b3990bca3368b193ef9
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spelling	oai:doaj.org-article:6cac17ed878a4b3990bca3368b193ef92021-12-02T14:01:38ZEarly β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice10.1038/s41598-020-79487-52045-2322https://doaj.org/article/6cac17ed878a4b3990bca3368b193ef92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79487-5https://doaj.org/toc/2045-2322Abstract In this study we demonstrate that 2 month old APPswe/PS1dE9 mice, a transgenic model of Alzheimer’s disease, exhibited intact short-term memory in Pavlovian hippocampal—dependent contextual fear learning task. However, their long-term memory was impaired. Intra-CA1 infusion of isoproterenol hydrochloride, the β-adrenoceptor agonist, to the ventral hippocampus of APPswe/PS1dE9 mice immediately before fear conditioning restored long-term contextual fear memory. Infusion of the β-adrenoceptor agonist + 2.5 h after fear conditioning only partially rescued the fear memory, whereas infusion at + 12 h post conditioning did not interfere with long-term memory persistence in this mouse model. Furthermore, Intra-CA1 infusion of propranolol, the β-adrenoceptor antagonist, administered immediately before conditioning to their wildtype counterpart impaired long-term fear memory, while it was ineffective when administered + 4 h and + 12 h post conditioning. Our results indicate that, long-term fear memory persistence is determined by a unique β-adrenoceptor sensitive time window between 0 and + 2.5 h upon learning acquisition, in the ventral hippocampal CA1 of APPswe/PS1dE9 mice. On the contrary, β-adrenoceptor agonist delivery to ventral hippocampal CA1 per se did not enhance innate anxiety behaviour in open field test. Thus we conclude that, activation of learning dependent early β-adrenoceptor modulation underlies and is necessary to promote long-term fear memory persistence in APPswe/PS1dE9.Smitha KarunakaranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Smitha Karunakaran Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
description	Abstract In this study we demonstrate that 2 month old APPswe/PS1dE9 mice, a transgenic model of Alzheimer’s disease, exhibited intact short-term memory in Pavlovian hippocampal—dependent contextual fear learning task. However, their long-term memory was impaired. Intra-CA1 infusion of isoproterenol hydrochloride, the β-adrenoceptor agonist, to the ventral hippocampus of APPswe/PS1dE9 mice immediately before fear conditioning restored long-term contextual fear memory. Infusion of the β-adrenoceptor agonist + 2.5 h after fear conditioning only partially rescued the fear memory, whereas infusion at + 12 h post conditioning did not interfere with long-term memory persistence in this mouse model. Furthermore, Intra-CA1 infusion of propranolol, the β-adrenoceptor antagonist, administered immediately before conditioning to their wildtype counterpart impaired long-term fear memory, while it was ineffective when administered + 4 h and + 12 h post conditioning. Our results indicate that, long-term fear memory persistence is determined by a unique β-adrenoceptor sensitive time window between 0 and + 2.5 h upon learning acquisition, in the ventral hippocampal CA1 of APPswe/PS1dE9 mice. On the contrary, β-adrenoceptor agonist delivery to ventral hippocampal CA1 per se did not enhance innate anxiety behaviour in open field test. Thus we conclude that, activation of learning dependent early β-adrenoceptor modulation underlies and is necessary to promote long-term fear memory persistence in APPswe/PS1dE9.
format	article
author	Smitha Karunakaran
author_facet	Smitha Karunakaran
author_sort	Smitha Karunakaran
title	Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
title_short	Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
title_full	Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
title_fullStr	Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
title_full_unstemmed	Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice
title_sort	early β adrenoceptor dependent time window for fear memory persistence in appswe/ps1de9 mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cac17ed878a4b3990bca3368b193ef9
work_keys_str_mv	AT smithakarunakaran earlybadrenoceptordependenttimewindowforfearmemorypersistenceinappsweps1de9mice
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Early β adrenoceptor dependent time window for fear memory persistence in APPswe/PS1dE9 mice

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