Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from...

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Autores principales: Jiaqi Liu, Haibo Zhou, Zhiyu Yang, Xue Wang, Hanna Chen, Lin Zhong, Wentao Zheng, Weijing Niu, Sen Wang, Xiangmei Ren, Guannan Zhong, Yan Wang, Xiaoming Ding, Rolf Müller, Youming Zhang, Xiaoying Bian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6cad4f276e794a0a8b1e4afc89aa72cf
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Sumario:An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from Chitinimonas koreensis.

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