Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from...

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Autores principales:	Jiaqi Liu, Haibo Zhou, Zhiyu Yang, Xue Wang, Hanna Chen, Lin Zhong, Wentao Zheng, Weijing Niu, Sen Wang, Xiangmei Ren, Guannan Zhong, Yan Wang, Xiaoming Ding, Rolf Müller, Youming Zhang, Xiaoying Bian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cad4f276e794a0a8b1e4afc89aa72cf
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spelling	oai:doaj.org-article:6cad4f276e794a0a8b1e4afc89aa72cf2021-12-02T16:18:02ZRational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria10.1038/s41467-021-24645-02041-1723https://doaj.org/article/6cad4f276e794a0a8b1e4afc89aa72cf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24645-0https://doaj.org/toc/2041-1723An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from Chitinimonas koreensis.Jiaqi LiuHaibo ZhouZhiyu YangXue WangHanna ChenLin ZhongWentao ZhengWeijing NiuSen WangXiangmei RenGuannan ZhongYan WangXiaoming DingRolf MüllerYouming ZhangXiaoying BianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiaqi Liu Haibo Zhou Zhiyu Yang Xue Wang Hanna Chen Lin Zhong Wentao Zheng Weijing Niu Sen Wang Xiangmei Ren Guannan Zhong Yan Wang Xiaoming Ding Rolf Müller Youming Zhang Xiaoying Bian Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
description	An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from Chitinimonas koreensis.
format	article
author	Jiaqi Liu Haibo Zhou Zhiyu Yang Xue Wang Hanna Chen Lin Zhong Wentao Zheng Weijing Niu Sen Wang Xiangmei Ren Guannan Zhong Yan Wang Xiaoming Ding Rolf Müller Youming Zhang Xiaoying Bian
author_facet	Jiaqi Liu Haibo Zhou Zhiyu Yang Xue Wang Hanna Chen Lin Zhong Wentao Zheng Weijing Niu Sen Wang Xiangmei Ren Guannan Zhong Yan Wang Xiaoming Ding Rolf Müller Youming Zhang Xiaoying Bian
author_sort	Jiaqi Liu
title	Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
title_short	Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
title_full	Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
title_fullStr	Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
title_full_unstemmed	Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
title_sort	rational construction of genome-reduced burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cad4f276e794a0a8b1e4afc89aa72cf
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_version_	1718384235907121152

Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

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