Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer

Adriamycin (ADR) is an important chemotherapy agent in many advanced cancers, but the emergence of drug resistance during treatment is a major limitation to its successful use. Recent studies have suggested that drug-resistant cells become less fit and their growth could be inhibited by parental cel...

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Autores principales:	Qi Min, Xie Lijuan, Duan Guihua
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	adriamycin resistance cervical cancer fitness differences tumor evolution Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6cad66f315dc43448fb0063f12084c42
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spelling	oai:doaj.org-article:6cad66f315dc43448fb0063f12084c422021-12-05T14:10:40ZAdriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer2391-541210.1515/biol-2021-0004https://doaj.org/article/6cad66f315dc43448fb0063f12084c422021-01-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0004https://doaj.org/toc/2391-5412Adriamycin (ADR) is an important chemotherapy agent in many advanced cancers, but the emergence of drug resistance during treatment is a major limitation to its successful use. Recent studies have suggested that drug-resistant cells become less fit and their growth could be inhibited by parental cells without cytotoxic treatment. In this study, we examined the fitness differences between HeLa and HeLa/ADR cells. Compared with the parental cell line, HeLa/ADR cells showed significantly lower growth rates, both in vitro and in vivo. There was no difference in the apoptosis rate between them, but G1 arrest and reduced DNA synthesis were found in HeLa/ADR cells. Further study indicated that HeLa/ADR cells failed to compete for space and nutrition against parental cells in vivo. Taken together, we demonstrate that HeLa/ADR cells are less fit and their growth can be inhibited by parental cells in the absence of ADR; therefore, the maintenance of a certain amount of ADR-sensitive cells during treatment may facilitate the control of the development of ADR resistance.Qi MinXie LijuanDuan GuihuaDe Gruyterarticleadriamycin resistancecervical cancerfitness differencestumor evolutionBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 53-60 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adriamycin resistance cervical cancer fitness differences tumor evolution Biology (General) QH301-705.5
spellingShingle	adriamycin resistance cervical cancer fitness differences tumor evolution Biology (General) QH301-705.5 Qi Min Xie Lijuan Duan Guihua Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
description	Adriamycin (ADR) is an important chemotherapy agent in many advanced cancers, but the emergence of drug resistance during treatment is a major limitation to its successful use. Recent studies have suggested that drug-resistant cells become less fit and their growth could be inhibited by parental cells without cytotoxic treatment. In this study, we examined the fitness differences between HeLa and HeLa/ADR cells. Compared with the parental cell line, HeLa/ADR cells showed significantly lower growth rates, both in vitro and in vivo. There was no difference in the apoptosis rate between them, but G1 arrest and reduced DNA synthesis were found in HeLa/ADR cells. Further study indicated that HeLa/ADR cells failed to compete for space and nutrition against parental cells in vivo. Taken together, we demonstrate that HeLa/ADR cells are less fit and their growth can be inhibited by parental cells in the absence of ADR; therefore, the maintenance of a certain amount of ADR-sensitive cells during treatment may facilitate the control of the development of ADR resistance.
format	article
author	Qi Min Xie Lijuan Duan Guihua
author_facet	Qi Min Xie Lijuan Duan Guihua
author_sort	Qi Min
title	Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
title_short	Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
title_full	Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
title_fullStr	Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
title_full_unstemmed	Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
title_sort	adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/6cad66f315dc43448fb0063f12084c42
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Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer

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