Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insu...
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Nature Portfolio
2017
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oai:doaj.org-article:6cad9665c7444f18bff6f14402e7b7b52021-12-02T17:01:17ZSox5 regulates beta-cell phenotype and is reduced in type 2 diabetes10.1038/ncomms156522041-1723https://doaj.org/article/6cad9665c7444f18bff6f14402e7b7b52017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15652https://doaj.org/toc/2041-1723Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets.A. S. AxelssonT. MahdiH. A. NenonenT. SinghS. HänzelmannA. WendtA. BaggeT. M. ReinbotheJ. MillsteinX. YangB. ZhangE. G. GusmaoL. ShuM. SzabatY. TangJ. WangS. SalöL. EliassonI. ArtnerM. FexJ. D. JohnsonC. B. WollheimJ.M.J. DerryB. MechamP. SpégelH. MulderI.G. CostaE. ZhangA. H. RosengrenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q A. S. Axelsson T. Mahdi H. A. Nenonen T. Singh S. Hänzelmann A. Wendt A. Bagge T. M. Reinbothe J. Millstein X. Yang B. Zhang E. G. Gusmao L. Shu M. Szabat Y. Tang J. Wang S. Salö L. Eliasson I. Artner M. Fex J. D. Johnson C. B. Wollheim J.M.J. Derry B. Mecham P. Spégel H. Mulder I.G. Costa E. Zhang A. H. Rosengren Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| description |
Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets. |
| format |
article |
| author |
A. S. Axelsson T. Mahdi H. A. Nenonen T. Singh S. Hänzelmann A. Wendt A. Bagge T. M. Reinbothe J. Millstein X. Yang B. Zhang E. G. Gusmao L. Shu M. Szabat Y. Tang J. Wang S. Salö L. Eliasson I. Artner M. Fex J. D. Johnson C. B. Wollheim J.M.J. Derry B. Mecham P. Spégel H. Mulder I.G. Costa E. Zhang A. H. Rosengren |
| author_facet |
A. S. Axelsson T. Mahdi H. A. Nenonen T. Singh S. Hänzelmann A. Wendt A. Bagge T. M. Reinbothe J. Millstein X. Yang B. Zhang E. G. Gusmao L. Shu M. Szabat Y. Tang J. Wang S. Salö L. Eliasson I. Artner M. Fex J. D. Johnson C. B. Wollheim J.M.J. Derry B. Mecham P. Spégel H. Mulder I.G. Costa E. Zhang A. H. Rosengren |
| author_sort |
A. S. Axelsson |
| title |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| title_short |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| title_full |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| title_fullStr |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| title_full_unstemmed |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| title_sort |
sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6cad9665c7444f18bff6f14402e7b7b5 |
| work_keys_str_mv |
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