Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health

Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the associat...

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Autores principales:	Irma Magaly Rivas Serna, Michal Sitina, Gorazd B. Stokin, Jose R. Medina-Inojosa, Francisco Lopez-Jimenez, Juan P. Gonzalez-Rivas, Manlio Vinciguerra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular health lipidomics sphingolipids phospholipids mass spectrometry Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6cb7512af4d34e3b8c9e91b8a7c160c4
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spelling	oai:doaj.org-article:6cb7512af4d34e3b8c9e91b8a7c160c42021-11-25T18:20:37ZLipidomic Profiling Identifies Signatures of Poor Cardiovascular Health10.3390/metabo111107472218-1989https://doaj.org/article/6cb7512af4d34e3b8c9e91b8a7c160c42021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/747https://doaj.org/toc/2218-1989Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the association of CVH metrics with the circulating lipid profile of a population-based cohort. Serum sphingolipid and phospholipid species were extracted from 461 patients of the randomly selected prospective Kardiovize study based on Brno, Czech Republic. Lipids species were measured by a hyphenated mass spectrometry technique, and were associated with poor CVH scores, as defined by the American Heart Association. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE) species were significantly lower in ideal and intermediate scores of health dietary metric, blood pressure, total cholesterol and blood fasting glucose compared to poor scores. Current smokers presented higher levels of PC, PE and LPE individual species compared to non-smokers. Ceramide (Cer) d18:1/14:0 was altered in poor blood pressure, total cholesterol and fasting blood glucose metrics. Poor cardiovascular health metric is associated with a specific phospho- and sphingolipid pattern. Circulatory lipid profiling is a potential biomarker to refine cardiovascular health status in primary prevention strategies.Irma Magaly Rivas SernaMichal SitinaGorazd B. StokinJose R. Medina-InojosaFrancisco Lopez-JimenezJuan P. Gonzalez-RivasManlio VinciguerraMDPI AGarticlecardiovascular healthlipidomicssphingolipidsphospholipidsmass spectrometryMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 747, p 747 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular health lipidomics sphingolipids phospholipids mass spectrometry Microbiology QR1-502
spellingShingle	cardiovascular health lipidomics sphingolipids phospholipids mass spectrometry Microbiology QR1-502 Irma Magaly Rivas Serna Michal Sitina Gorazd B. Stokin Jose R. Medina-Inojosa Francisco Lopez-Jimenez Juan P. Gonzalez-Rivas Manlio Vinciguerra Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
description	Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the association of CVH metrics with the circulating lipid profile of a population-based cohort. Serum sphingolipid and phospholipid species were extracted from 461 patients of the randomly selected prospective Kardiovize study based on Brno, Czech Republic. Lipids species were measured by a hyphenated mass spectrometry technique, and were associated with poor CVH scores, as defined by the American Heart Association. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE) species were significantly lower in ideal and intermediate scores of health dietary metric, blood pressure, total cholesterol and blood fasting glucose compared to poor scores. Current smokers presented higher levels of PC, PE and LPE individual species compared to non-smokers. Ceramide (Cer) d18:1/14:0 was altered in poor blood pressure, total cholesterol and fasting blood glucose metrics. Poor cardiovascular health metric is associated with a specific phospho- and sphingolipid pattern. Circulatory lipid profiling is a potential biomarker to refine cardiovascular health status in primary prevention strategies.
format	article
author	Irma Magaly Rivas Serna Michal Sitina Gorazd B. Stokin Jose R. Medina-Inojosa Francisco Lopez-Jimenez Juan P. Gonzalez-Rivas Manlio Vinciguerra
author_facet	Irma Magaly Rivas Serna Michal Sitina Gorazd B. Stokin Jose R. Medina-Inojosa Francisco Lopez-Jimenez Juan P. Gonzalez-Rivas Manlio Vinciguerra
author_sort	Irma Magaly Rivas Serna
title	Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
title_short	Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
title_full	Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
title_fullStr	Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
title_full_unstemmed	Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health
title_sort	lipidomic profiling identifies signatures of poor cardiovascular health
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6cb7512af4d34e3b8c9e91b8a7c160c4
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Lipidomic Profiling Identifies Signatures of Poor Cardiovascular Health

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