Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study

Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ulf Schött, Cecilia Augustsson, Luukas Lilover, Caroline Ulfsdotter Nilsson, Louise Walther-Sturesson, Thomas Kander
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Gas6 Axl receptor endothelial dysfunction prothrombin time Gla protein thrombin generation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6cb86dea8f2f4edf95dff760a8cec8be
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6cb86dea8f2f4edf95dff760a8cec8be
record_format	dspace
spelling	oai:doaj.org-article:6cb86dea8f2f4edf95dff760a8cec8be2021-11-25T18:36:45ZVitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study10.3390/nu131141012072-6643https://doaj.org/article/6cb86dea8f2f4edf95dff760a8cec8be2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4101https://doaj.org/toc/2072-6643Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) > 1.2 and blood samples were retrieved before and 20–28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20–28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.Ulf SchöttCecilia AugustssonLuukas LiloverCaroline Ulfsdotter NilssonLouise Walther-SturessonThomas KanderMDPI AGarticleGas6Axl receptorendothelial dysfunctionprothrombin timeGla proteinthrombin generationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4101, p 4101 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gas6 Axl receptor endothelial dysfunction prothrombin time Gla protein thrombin generation Nutrition. Foods and food supply TX341-641
spellingShingle	Gas6 Axl receptor endothelial dysfunction prothrombin time Gla protein thrombin generation Nutrition. Foods and food supply TX341-641 Ulf Schött Cecilia Augustsson Luukas Lilover Caroline Ulfsdotter Nilsson Louise Walther-Sturesson Thomas Kander Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
description	Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) > 1.2 and blood samples were retrieved before and 20–28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20–28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.
format	article
author	Ulf Schött Cecilia Augustsson Luukas Lilover Caroline Ulfsdotter Nilsson Louise Walther-Sturesson Thomas Kander
author_facet	Ulf Schött Cecilia Augustsson Luukas Lilover Caroline Ulfsdotter Nilsson Louise Walther-Sturesson Thomas Kander
author_sort	Ulf Schött
title	Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
title_short	Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
title_full	Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
title_fullStr	Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
title_full_unstemmed	Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
title_sort	vitamin k effects on gas6 and soluble axl receptors in intensive care patients: an observational screening study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6cb86dea8f2f4edf95dff760a8cec8be
work_keys_str_mv	AT ulfschott vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy AT ceciliaaugustsson vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy AT luukaslilover vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy AT carolineulfsdotternilsson vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy AT louisewalthersturesson vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy AT thomaskander vitaminkeffectsongas6andsolubleaxlreceptorsinintensivecarepatientsanobservationalscreeningstudy
_version_	1718410896445800448

Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study

Ejemplares similares