Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbst...

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Autores principales:	Sudharshan Reddy D, Muchandi IS, Srinivasa Rao A, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6cba3500aa604b7a8639271be1815869
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spelling	oai:doaj.org-article:6cba3500aa604b7a8639271be18158692021-12-02T00:25:47ZEffect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice1178-7007https://doaj.org/article/6cba3500aa604b7a8639271be18158692010-04-01T00:00:00Zhttp://www.dovepress.com/effect-of-holostemma-annularis-on-the-progression-of-diabetes-induced--a4314https://doaj.org/toc/1178-7007Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob mice Sudharshan Reddy DMuchandi ISSrinivasa Rao Aet alDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 87-94 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Sudharshan Reddy D Muchandi IS Srinivasa Rao A et al Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
description	Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob mice
format	article
author	Sudharshan Reddy D Muchandi IS Srinivasa Rao A et al
author_facet	Sudharshan Reddy D Muchandi IS Srinivasa Rao A et al
author_sort	Sudharshan Reddy D
title	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_short	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_full	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_fullStr	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_full_unstemmed	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_sort	effect of holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic c57bl/6j ob/ob mice
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/6cba3500aa604b7a8639271be1815869
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Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

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