The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis

Abstract Autoimmune encephalitis (AE) is an inflammatory brain disease which is frequently associated with antibodies (Abs) against cell-surface, synaptic or intracellular neuronal proteins. There is increasing evidence that dendritic cells (DCs) are implicated as key modulators in keeping the balan...

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Autores principales:	Fatme Seval Ismail, Sven G. Meuth, Nico Melzer
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dendritic cells B cells T cells Antibodies Autoimmune encephalitis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6cbafa9f6c134c98b76ef8dee400bde7
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spelling	oai:doaj.org-article:6cbafa9f6c134c98b76ef8dee400bde72021-11-14T12:38:15ZThe role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis10.1186/s12974-021-02310-z1742-2094https://doaj.org/article/6cbafa9f6c134c98b76ef8dee400bde72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12974-021-02310-zhttps://doaj.org/toc/1742-2094Abstract Autoimmune encephalitis (AE) is an inflammatory brain disease which is frequently associated with antibodies (Abs) against cell-surface, synaptic or intracellular neuronal proteins. There is increasing evidence that dendritic cells (DCs) are implicated as key modulators in keeping the balance between immune response and tolerance in the CNS. Migratory features of DCs to and from the brain are linked to initiating and maintaining of neuroinflammation. Genetic polymorphisms together with other triggers such as systemic or cerebral viral infection, or systemic malignancies could contribute to the dysbalance of “regulatory” and “encephalitogenic” DCs with subsequent dysregulated T and B cell reactions in AE. Novel in vivo models with implantation of mature DCs containing neuronal antigens could help to study the pathogenesis and perhaps to understand the origin of AE. Investigations of DCs in human blood, lymphoid tissues, CSF, and brain parenchyma of patients with AE are necessary to deepen our knowledge about the complex interactions between DCs, T and B cells during neuroinflammation in AE. This can support developing new therapy strategies.Fatme Seval IsmailSven G. MeuthNico MelzerBMCarticleDendritic cellsB cellsT cellsAntibodiesAutoimmune encephalitisNeurology. Diseases of the nervous systemRC346-429ENJournal of Neuroinflammation, Vol 18, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dendritic cells B cells T cells Antibodies Autoimmune encephalitis Neurology. Diseases of the nervous system RC346-429
spellingShingle	Dendritic cells B cells T cells Antibodies Autoimmune encephalitis Neurology. Diseases of the nervous system RC346-429 Fatme Seval Ismail Sven G. Meuth Nico Melzer The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
description	Abstract Autoimmune encephalitis (AE) is an inflammatory brain disease which is frequently associated with antibodies (Abs) against cell-surface, synaptic or intracellular neuronal proteins. There is increasing evidence that dendritic cells (DCs) are implicated as key modulators in keeping the balance between immune response and tolerance in the CNS. Migratory features of DCs to and from the brain are linked to initiating and maintaining of neuroinflammation. Genetic polymorphisms together with other triggers such as systemic or cerebral viral infection, or systemic malignancies could contribute to the dysbalance of “regulatory” and “encephalitogenic” DCs with subsequent dysregulated T and B cell reactions in AE. Novel in vivo models with implantation of mature DCs containing neuronal antigens could help to study the pathogenesis and perhaps to understand the origin of AE. Investigations of DCs in human blood, lymphoid tissues, CSF, and brain parenchyma of patients with AE are necessary to deepen our knowledge about the complex interactions between DCs, T and B cells during neuroinflammation in AE. This can support developing new therapy strategies.
format	article
author	Fatme Seval Ismail Sven G. Meuth Nico Melzer
author_facet	Fatme Seval Ismail Sven G. Meuth Nico Melzer
author_sort	Fatme Seval Ismail
title	The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
title_short	The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
title_full	The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
title_fullStr	The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
title_full_unstemmed	The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
title_sort	role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6cbafa9f6c134c98b76ef8dee400bde7
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The role of dendritic cells and their interactions in the pathogenesis of antibody-associated autoimmune encephalitis

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