A functionally significant SNP in TP53 and breast cancer risk in African-American women
Genetics: Variant may increase cancer risk in pre-menopausal black women A gene variant found in people of African descent may increase the risk of breast cancer—but only among pre-menopausal women. In a study of more than 14,000 women of African ancestry, a team led by Maureen Murphy from the Wista...
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Nature Portfolio
2017
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oai:doaj.org-article:6cbf07c525e841a38a28b2739e09d08a2021-12-02T12:30:31ZA functionally significant SNP in TP53 and breast cancer risk in African-American women10.1038/s41523-017-0007-92374-4677https://doaj.org/article/6cbf07c525e841a38a28b2739e09d08a2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0007-9https://doaj.org/toc/2374-4677Genetics: Variant may increase cancer risk in pre-menopausal black women A gene variant found in people of African descent may increase the risk of breast cancer—but only among pre-menopausal women. In a study of more than 14,000 women of African ancestry, a team led by Maureen Murphy from the Wistar Institute in Philadelphia, Pennsylvania, USA, and Christine Ambrosone from Roswell Park Cancer Institute in Buffalo, NY, USA, tested for an association between breast cancer and a rare genetic polymorphism in the TP53 gene that’s found almost exclusively in African-descent populations. This variant alters the p53 tumor suppressor protein and has been shown to increase cancer risk in a mouse model. Murphy and colleagues showed that the variant increased risk by about 72% in women who had not yet experienced menopause—which could help explain the earlier onset of the disease among women of African ancestry.Maureen E. MurphySong LiuSong YaoDezheng HuoQin LiuSonia C. DolfiKim M. HirshfieldChi-Chen HongQiang HuAndrew F. OlshanTemidayo O. OgundiranClement AdebamowoSusan M. DomchekKatherine L. NathansonBarbara NemesureStefan AmbsWilliam J. BlotYe FengEsther M. JohnLeslie BernsteinWei ZhengJennifer J. HuRegina G. ZieglerSarah NyanteSue A. InglesMichael F. PressSandra L. DemingJorge L. Rodriguez-GilChristopher A. HaimanOlufunmilayo I. OlopadeKathryn L. LunettaJulie R. PalmerChristine B. AmbrosoneNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-4 (2017) |
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DOAJ |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Maureen E. Murphy Song Liu Song Yao Dezheng Huo Qin Liu Sonia C. Dolfi Kim M. Hirshfield Chi-Chen Hong Qiang Hu Andrew F. Olshan Temidayo O. Ogundiran Clement Adebamowo Susan M. Domchek Katherine L. Nathanson Barbara Nemesure Stefan Ambs William J. Blot Ye Feng Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Sue A. Ingles Michael F. Press Sandra L. Deming Jorge L. Rodriguez-Gil Christopher A. Haiman Olufunmilayo I. Olopade Kathryn L. Lunetta Julie R. Palmer Christine B. Ambrosone A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| description |
Genetics: Variant may increase cancer risk in pre-menopausal black women A gene variant found in people of African descent may increase the risk of breast cancer—but only among pre-menopausal women. In a study of more than 14,000 women of African ancestry, a team led by Maureen Murphy from the Wistar Institute in Philadelphia, Pennsylvania, USA, and Christine Ambrosone from Roswell Park Cancer Institute in Buffalo, NY, USA, tested for an association between breast cancer and a rare genetic polymorphism in the TP53 gene that’s found almost exclusively in African-descent populations. This variant alters the p53 tumor suppressor protein and has been shown to increase cancer risk in a mouse model. Murphy and colleagues showed that the variant increased risk by about 72% in women who had not yet experienced menopause—which could help explain the earlier onset of the disease among women of African ancestry. |
| format |
article |
| author |
Maureen E. Murphy Song Liu Song Yao Dezheng Huo Qin Liu Sonia C. Dolfi Kim M. Hirshfield Chi-Chen Hong Qiang Hu Andrew F. Olshan Temidayo O. Ogundiran Clement Adebamowo Susan M. Domchek Katherine L. Nathanson Barbara Nemesure Stefan Ambs William J. Blot Ye Feng Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Sue A. Ingles Michael F. Press Sandra L. Deming Jorge L. Rodriguez-Gil Christopher A. Haiman Olufunmilayo I. Olopade Kathryn L. Lunetta Julie R. Palmer Christine B. Ambrosone |
| author_facet |
Maureen E. Murphy Song Liu Song Yao Dezheng Huo Qin Liu Sonia C. Dolfi Kim M. Hirshfield Chi-Chen Hong Qiang Hu Andrew F. Olshan Temidayo O. Ogundiran Clement Adebamowo Susan M. Domchek Katherine L. Nathanson Barbara Nemesure Stefan Ambs William J. Blot Ye Feng Esther M. John Leslie Bernstein Wei Zheng Jennifer J. Hu Regina G. Ziegler Sarah Nyante Sue A. Ingles Michael F. Press Sandra L. Deming Jorge L. Rodriguez-Gil Christopher A. Haiman Olufunmilayo I. Olopade Kathryn L. Lunetta Julie R. Palmer Christine B. Ambrosone |
| author_sort |
Maureen E. Murphy |
| title |
A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| title_short |
A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| title_full |
A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| title_fullStr |
A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| title_full_unstemmed |
A functionally significant SNP in TP53 and breast cancer risk in African-American women |
| title_sort |
functionally significant snp in tp53 and breast cancer risk in african-american women |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6cbf07c525e841a38a28b2739e09d08a |
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