The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

Export of proteins by type three secretion systems occurs through an export gate that is localized in the periplasm. Here, the authors present the cryo-EM structure of the Vibrio mimicus export gate complex with FlhB, which plays a major role in switching of the specificity of secretion substrates a...

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Autores principales:	Lucas Kuhlen, Steven Johnson, Andreas Zeitler, Sandra Bäurle, Justin C. Deme, Joseph J. E. Caesar, Rebecca Debo, Joseph Fisher, Samuel Wagner, Susan M. Lea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cc514e45205439e8975bcd521c5273c
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spelling	oai:doaj.org-article:6cc514e45205439e8975bcd521c5273c2021-12-02T14:40:51ZThe substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion10.1038/s41467-020-15071-92041-1723https://doaj.org/article/6cc514e45205439e8975bcd521c5273c2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15071-9https://doaj.org/toc/2041-1723Export of proteins by type three secretion systems occurs through an export gate that is localized in the periplasm. Here, the authors present the cryo-EM structure of the Vibrio mimicus export gate complex with FlhB, which plays a major role in switching of the specificity of secretion substrates and propose a mechanism for export gate opening.Lucas KuhlenSteven JohnsonAndreas ZeitlerSandra BäurleJustin C. DemeJoseph J. E. CaesarRebecca DeboJoseph FisherSamuel WagnerSusan M. LeaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucas Kuhlen Steven Johnson Andreas Zeitler Sandra Bäurle Justin C. Deme Joseph J. E. Caesar Rebecca Debo Joseph Fisher Samuel Wagner Susan M. Lea The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
description	Export of proteins by type three secretion systems occurs through an export gate that is localized in the periplasm. Here, the authors present the cryo-EM structure of the Vibrio mimicus export gate complex with FlhB, which plays a major role in switching of the specificity of secretion substrates and propose a mechanism for export gate opening.
format	article
author	Lucas Kuhlen Steven Johnson Andreas Zeitler Sandra Bäurle Justin C. Deme Joseph J. E. Caesar Rebecca Debo Joseph Fisher Samuel Wagner Susan M. Lea
author_facet	Lucas Kuhlen Steven Johnson Andreas Zeitler Sandra Bäurle Justin C. Deme Joseph J. E. Caesar Rebecca Debo Joseph Fisher Samuel Wagner Susan M. Lea
author_sort	Lucas Kuhlen
title	The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
title_short	The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
title_full	The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
title_fullStr	The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
title_full_unstemmed	The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
title_sort	substrate specificity switch flhb assembles onto the export gate to regulate type three secretion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6cc514e45205439e8975bcd521c5273c
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The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

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