Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>

The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and ext...

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Autores principales:	Sukee Sukdee, Puttinan Meepowpan, Narong Nantasaen, Siriporn Jungsuttiwong, Sarinya Hadsadee, Wilart Pompimon
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	mitrephora winitii anticancer extraction extract Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6cc574314b8f4e70bd60e0003c9753d2
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spelling	oai:doaj.org-article:6cc574314b8f4e70bd60e0003c9753d22021-12-02T17:59:54ZAnticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>1411-94202460-157810.22146/ijc.61085https://doaj.org/article/6cc574314b8f4e70bd60e0003c9753d22021-04-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/61085https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.Sukee SukdeePuttinan MeepowpanNarong NantasaenSiriporn JungsuttiwongSarinya HadsadeeWilart PompimonDepartment of Chemistry, Universitas Gadjah Madaarticlemitrephora winitiianticancerextractionextractChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 3, Pp 699-707 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitrephora winitii anticancer extraction extract Chemistry QD1-999
spellingShingle	mitrephora winitii anticancer extraction extract Chemistry QD1-999 Sukee Sukdee Puttinan Meepowpan Narong Nantasaen Siriporn Jungsuttiwong Sarinya Hadsadee Wilart Pompimon Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
description	The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.
format	article
author	Sukee Sukdee Puttinan Meepowpan Narong Nantasaen Siriporn Jungsuttiwong Sarinya Hadsadee Wilart Pompimon
author_facet	Sukee Sukdee Puttinan Meepowpan Narong Nantasaen Siriporn Jungsuttiwong Sarinya Hadsadee Wilart Pompimon
author_sort	Sukee Sukdee
title	Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
title_short	Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
title_full	Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
title_fullStr	Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
title_full_unstemmed	Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>
title_sort	anticancer activities of chemical constituents from leaves and twigs of <i>mitrephora winitii</i>
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/6cc574314b8f4e70bd60e0003c9753d2
work_keys_str_mv	AT sukeesukdee anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii AT puttinanmeepowpan anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii AT narongnantasaen anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii AT siripornjungsuttiwong anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii AT sarinyahadsadee anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii AT wilartpompimon anticanceractivitiesofchemicalconstituentsfromleavesandtwigsofimitrephorawinitiii
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Anticancer Activities of Chemical Constituents from Leaves and Twigs of <i>Mitrephora winitii</i>

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