Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.

Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified a...

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Autores principales:	Eduardo Gómez-Gómez, Martín Efrén Ríos-Martínez, Elena Margarita Castro-Rodríguez, Mario Del-Toro-Equíhua, Mario Ramírez-Flores, Ivan Delgado-Enciso, Ana Lilia Pérez-Huitimea, Luz Margarita Baltazar-Rodríguez, Gilberto Velasco-Pineda, Jesús Muñiz-Murguía
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6cc58cd7903b498480276f88291b7d8f
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spelling	oai:doaj.org-article:6cc58cd7903b498480276f88291b7d8f2021-11-18T08:16:49ZCarnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.1932-620310.1371/journal.pone.0096791https://doaj.org/article/6cc58cd7903b498480276f88291b7d8f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905907/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified as indicators of obesity in population studies. It is therefore important to understand the effects of these mutations on ADRB3 and CPT1B function in adipose and skeletal muscle tissue, respectively. This study aimed to analyze the rate of lipolysis of plasma indicators (glycerol, free fatty acids, and beta hydroxybutyrate) and fat oxidation (through the non-protein respiratory quotient). These parameters were measured in 37 participants during 30 min of aerobic exercise at approximately 62% of maximal oxygen uptake, followed by 30 min of recovery. During recovery, mean respiratory quotient values were higher in K allele carriers than in non-carriers, indicating low post-exercise fatty acid oxidation rates. No significant differences in lipolysis or lipid oxidation were observed between R and W allele carriers of ADRB3 at any time during the aerobic load. The substitution of glutamic acid at position 531 by lysine in the CPT1B protein decreases the mitochondrial beta-oxidation pathway, which increases the non-protein respiratory quotient value during recovery from exercise. This may contribute to weight gain or reduced weight-loss following exercise.Eduardo Gómez-GómezMartín Efrén Ríos-MartínezElena Margarita Castro-RodríguezMario Del-Toro-EquíhuaMario Ramírez-FloresIvan Delgado-EncisoAna Lilia Pérez-HuitimeaLuz Margarita Baltazar-RodríguezGilberto Velasco-PinedaJesús Muñiz-MurguíaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e96791 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eduardo Gómez-Gómez Martín Efrén Ríos-Martínez Elena Margarita Castro-Rodríguez Mario Del-Toro-Equíhua Mario Ramírez-Flores Ivan Delgado-Enciso Ana Lilia Pérez-Huitimea Luz Margarita Baltazar-Rodríguez Gilberto Velasco-Pineda Jesús Muñiz-Murguía Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
description	Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified as indicators of obesity in population studies. It is therefore important to understand the effects of these mutations on ADRB3 and CPT1B function in adipose and skeletal muscle tissue, respectively. This study aimed to analyze the rate of lipolysis of plasma indicators (glycerol, free fatty acids, and beta hydroxybutyrate) and fat oxidation (through the non-protein respiratory quotient). These parameters were measured in 37 participants during 30 min of aerobic exercise at approximately 62% of maximal oxygen uptake, followed by 30 min of recovery. During recovery, mean respiratory quotient values were higher in K allele carriers than in non-carriers, indicating low post-exercise fatty acid oxidation rates. No significant differences in lipolysis or lipid oxidation were observed between R and W allele carriers of ADRB3 at any time during the aerobic load. The substitution of glutamic acid at position 531 by lysine in the CPT1B protein decreases the mitochondrial beta-oxidation pathway, which increases the non-protein respiratory quotient value during recovery from exercise. This may contribute to weight gain or reduced weight-loss following exercise.
format	article
author	Eduardo Gómez-Gómez Martín Efrén Ríos-Martínez Elena Margarita Castro-Rodríguez Mario Del-Toro-Equíhua Mario Ramírez-Flores Ivan Delgado-Enciso Ana Lilia Pérez-Huitimea Luz Margarita Baltazar-Rodríguez Gilberto Velasco-Pineda Jesús Muñiz-Murguía
author_facet	Eduardo Gómez-Gómez Martín Efrén Ríos-Martínez Elena Margarita Castro-Rodríguez Mario Del-Toro-Equíhua Mario Ramírez-Flores Ivan Delgado-Enciso Ana Lilia Pérez-Huitimea Luz Margarita Baltazar-Rodríguez Gilberto Velasco-Pineda Jesús Muñiz-Murguía
author_sort	Eduardo Gómez-Gómez
title	Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
title_short	Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
title_full	Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
title_fullStr	Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
title_full_unstemmed	Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.
title_sort	carnitine palmitoyltransferase 1b 531k allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64r allele does not affect lipolysis: a human model.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6cc58cd7903b498480276f88291b7d8f
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Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but β3-adrenoceptor 64R allele does not affect lipolysis: a human model.

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