De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ+ preadipocytes and...

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Autores principales:	Mengle Shao, Lavanya Vishvanath, Napoleon C. Busbuso, Chelsea Hepler, Bo Shan, Ankit X. Sharma, Shiuhwei Chen, Xinxin Yu, Yu A. An, Yi Zhu, William L. Holland, Rana K. Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb9
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spelling	oai:doaj.org-article:6cc640ee069d48bba9a616e022b49eb92021-12-02T16:56:35ZDe novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity10.1038/s41467-018-03196-x2041-1723https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb92018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03196-xhttps://doaj.org/toc/2041-1723Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ+ preadipocytes and show that this protects from pathological WAT remodeling.Mengle ShaoLavanya VishvanathNapoleon C. BusbusoChelsea HeplerBo ShanAnkit X. SharmaShiuhwei ChenXinxin YuYu A. AnYi ZhuWilliam L. HollandRana K. GuptaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengle Shao Lavanya Vishvanath Napoleon C. Busbuso Chelsea Hepler Bo Shan Ankit X. Sharma Shiuhwei Chen Xinxin Yu Yu A. An Yi Zhu William L. Holland Rana K. Gupta De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
description	Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible overexpression of Pparg in Pdgfrβ+ preadipocytes and show that this protects from pathological WAT remodeling.
format	article
author	Mengle Shao Lavanya Vishvanath Napoleon C. Busbuso Chelsea Hepler Bo Shan Ankit X. Sharma Shiuhwei Chen Xinxin Yu Yu A. An Yi Zhu William L. Holland Rana K. Gupta
author_facet	Mengle Shao Lavanya Vishvanath Napoleon C. Busbuso Chelsea Hepler Bo Shan Ankit X. Sharma Shiuhwei Chen Xinxin Yu Yu A. An Yi Zhu William L. Holland Rana K. Gupta
author_sort	Mengle Shao
title	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
title_short	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
title_full	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
title_fullStr	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
title_full_unstemmed	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
title_sort	de novo adipocyte differentiation from pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb9
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De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

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